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Redox active or thiol reactive? Optimization of rapid screens to identify less evident nuisance compoundsProj, Matic ...Compounds that exhibit assay interference or undesirable mechanisms of bioactivity are routinely encountered in assays at various stages of drug discovery. We observed that assays for the ... investigation of thiol-reactive and redox-active compounds have not been collected in a comprehensive review. Here, we review these assays and subject them to experimental optimization to improve their reliability. We demonstrate the usefulness of our assay cascade by assaying a library of bioactive compounds, chemical probes, and a set of approved drugs. These high-throughput assays should complement the array of wet-lab and in silico assays during the initial stages of hit discovery campaigns to pursue only hit compounds with tractable mechanisms of action.Source: Drug discovery today. - ISSN 1359-6446 (Vol. 27, iss. 6, 2022, str. 1733-1742)Type of material - article, component part ; adult, seriousPublish date - 2022Language - englishCOBISS.SI-ID - 100881923
Author
Proj, Matic |
Knez, Damijan, farmacevt |
Sosič, Izidor |
Gobec, Stanislav, 1970-
Topics
Farmacevtska kemija |
Zdravila |
edox |
covalent |
screening |
hits |
PAINS |
assays |
redoks |
kovalentni presejalni pregled |
testi
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DRS, in which the journal is indexed
Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Proj, Matic | 52376 |
Knez, Damijan, farmacevt | 36438 |
Sosič, Izidor | 30816 |
Gobec, Stanislav, 1970- | 15284 |
Source: Personal bibliographies
and: SICRIS
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