Functional topology in a network of protein interactions
Pržulj, Nataša, 1973- ; Wigle, D. A. ; Jurisica, I.
Motivation: The building blocks of biological networks are individual protein-protein interactions (PPIs). The cumulative PPI data set in Saccharomyces cerevisiae now exceeds 78 000. Studying the ...network of these interactions will provide valuable insight into the inner workings of cells. Results:We performed a systematic graph theory-based analysis of this PPI network to construct computational models for describing and predicting the properties of lethal mutations and proteins participating in genetic interactions, functional groups, protein complexes and signaling pathways. Ouranalysis suggests that lethal mutations are not only highly connected within the network, but they also satisfy an additional property: their removal causes a disruption in network structure. We also provide evidence forthe existence of alternate paths that bypass viable proteins in PPI networks, while such paths do not exist for lethal mutations. In addition, we show that distinct functional classes of proteins have differing network properties.We also demonstrate a way to extract and iteratively predict protein complexes and signaling pathways. We evaluate the power of predictionsby comparing them with a random model, and assess accuracy of predictions by analyzing their overlap with MIPS database. Conclusions: Our models provide a means for understanding the complex wiring underlying cellular function, and enable us to predict essentiality, genetic interaction,function, protein complexes and cellular pathways. This analysis uncovers structure-function relationships observable in a large PPI network.
It was not necessary to add the material to the shelf.
Bibliographic material was successfully added on shelf.
Adding bibliographical material on shelf was not successful.
Material is already on the shelf.
Permalink
URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year
Impact factor
Edition
Category
Classification
JCR
SNIP
JCR
SNIP
JCR
SNIP
JCR
SNIP
Select the library membership card:
DRS,
in which the journal is indexed
Database name
Field
Year
Links to authors' personal bibliographies
Links to information on researchers in the SICRIS system
Subject headings in COBISS General List of Subject Headings
Select pickup location
The material from the parent unit is free. If the material is delivered to the pickup location from another unit, the library may charge you for this service.
PDF
