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Infiltrating natural killer cells bind, lyse and increase chemotherapy efficacy in glioblastoma stem-like tumorospheres [Elektronski vir]Breznik, Barbara, 1989- ...Glioblastomas remain the most lethal primary brain tumors. Natural killer (NK) cell-based therapy is a promising immunotherapeutic strategy in the treatment of glioblastomas, since these cells can ... select and lyse therapy-resistant glioblastoma stem-like cells (GSLCs). Immunotherapy with super-charged NK cells has a potential as antitumor approach since we found their efficiency to kill patient-derived GSLCs in 2D and 3D models, potentially reversing the immunosuppression also seen in the patients. In addition to their potent cytotoxicity, NK cells secrete IFN-γ, upregulate GSLC surface expression of CD54 and MHC class I and increase sensitivity of GSLCs to chemotherapeutic drugs. Moreover, NK cell localization in peri-vascular regions in glioblastoma tissues and their close contact with GSLCs in tumorospheres suggests their ability to infiltrate glioblastoma tumors and target GSLCs. Due to GSLC heterogeneity and plasticity in regards to their stage of differentiation personalized immunotherapeutic strategies should be designed to effectively target glioblastomas.Source: Communications biology [Elektronski vir]. - ISSN 2399-3642 (Vol. 5, 2022, str. 1-15)Type of material - e-articlePublish date - 2022Language - englishCOBISS.SI-ID - 107677443
Author
Breznik, Barbara, 1989- |
Ko, Meng-Wei |
Tse, Christopher |
Chen, Po-Chun |
Senjor, Emanuela |
Majc, Bernarda |
Habič, Anamarija |
Angelillis, Nicolas |
Novak, Metka, biokemija, 1985- |
Župunski, Vera |
Mlakar, Jernej, medicina |
Nathanson, David |
Jewett, Anahid
Topics
glioblastom |
naravne celice ubijalke |
translacijska onkologija |
glioblastoma |
natural killer cells |
translational oncology
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Author | Breznik, Barbara, 1989- ... |
Title | Infiltrating natural killer cells bind, lyse and increase chemotherapy efficacy in glioblastoma stem-like tumorospheres [Elektronski vir] |
Publication date | 2022-05-10 |
COBISS.SI-ID | 107677443 |
Publication version in repository | Publisher's version |
Publication licence | Creative Commons Attribution 4.0 International |
Embargo | Immediate publication for public |
Project(s) from which the publication was funded
Title | Acronym | Project ID | Funder |
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Ekotoksiologija, toksikološka genomika in karcinogeneza | P1-0245-2019 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
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Toksini in biomembrane | P1-0207-2020 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
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Okvare jedrnega transporta pri nevrodegenerativnih boleznih | J3-8201-2017 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
|
Vpliv mezenhimskih matičnih celic na odpornost glioblastoma na terapijo | Z3-1870-2019 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Breznik, Barbara, 1989- | 36319 |
Ko, Meng-Wei | ![]() |
Tse, Christopher | ![]() |
Chen, Po-Chun | ![]() |
Senjor, Emanuela | 51713 |
Majc, Bernarda | 51984 |
Habič, Anamarija | 54677 |
Angelillis, Nicolas | ![]() |
Novak, Metka, biokemija, 1985- | 32116 |
Župunski, Vera | 15640 |
Mlakar, Jernej, medicina | 54927 |
Nathanson, David | ![]() |
Jewett, Anahid | ![]() |
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