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Literaturni pregled in ocena zdravstvene trditve izbranih zdravilnih učinkovin in prehranskih dopolnil z domnevnim učinkom upočasnjevanja staranja = Literature review and health claim assessment of selected drugs and dietary supplements with potential anti-aging properties : Uniform Master's Degree in PharmacyPodlesek, AlešStaranja zaenkrat ne obravnavamo kot nekaj patološkega, zato tudi ni uradno priznanih terapij oz. zdravil, s katerimi bi upočasnili ali celo ustavili proces staranja. V magistrski nalogi smo izbrali ... spojine, za katere »splet« trdi, da upočasnijo staranje: resveratrol, metformin, kurkumin, rapamicin in nikotinamid adenin dinukleotid. Z oblikovanjem iskalnih profilov za posamezne spojine smo v podatkovni bazi PubMed identificirali ustrezne članke v angleškem jeziku. Rezultate smo predstavili po posameznih spojinah (resveratrol, metformin, kurkumin, rapamicin in nikotinamid adenin dinukleotid). Ker trenutno registrirane učinkovine in prehranska dopolnila nimajo indikacije za upočasnitev staranja, smo v magistrski nalogi želeli raziskati, ali obstaja znanstvena podlaga za te trditve, četudi le na osnovi študij na modelnih organizmih. Poleg tega nas je zanimal mehanizem upočasnitve staranja. Ugotovili smo, da metformin, rapamicin in nikotinamid adenin dinukleotid upočasnijo procese staranja pri modelnih organizmih in da je mehanizem delovanja relativno raziskan. Tudi resveratrol po nekaterih študijah upočasni staranje modelnih organizmov, a je več polemik glede mehanizma delovanja, saj deluje na več tarč. Za kurkumin je narejenih premalo študij, da bi lahko naredili podoben zaključek kot pri prvih štirih. Nemogoče pa je prenesti rezultate teh študij na ljudi oz. odgovoriti na vprašanje, ali te učinkovine tudi statistično značilno vplivajo na upočasnitev staranja pri ljudeh in kakšni bi bili stranski učinki. Ker pa je potek staranja zelo povezan z metabolno aktivnostjo, bodo morda nekatere omenjene učinkovine oz. njihovi analogi postali pomembni pri zdravljenju sladkorne bolezni, kar bo ob kronični terapiji morda dalo odgovor na vprašanje, kako vplivajo na življenjsko dobo. Poleg obravnavanega literaturnega pregleda smo na koncu ocenili tudi zdravstvene trditve in tako komentirali povezavo med omenjenimi spojinami in zdravjem človeka.Type of material - master's thesis ; adult, seriousPublication and manufacture - Ljubljana : [A. Podlesek], 2022Language - slovenianCOBISS.SI-ID - 109768451
Author
Podlesek, Aleš
Other authors
Pajk, Stane, 1983-
Topics
Staranje |
resveratrol |
metformin |
kurkumin |
rapamicin |
nikotinamid adenin dinukleotid
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Library/institution |
City | Acronym | For loan | Other holdings |
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Faculty of Pharmacy, Ljubljana | Ljubljana | FFALJ |
reading room 1 cop.
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Year | Impact factor | Edition | Category | Classification | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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DRS, in which the journal is indexed
Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Podlesek, Aleš | ![]() |
Pajk, Stane, 1983- | 28861 |
Source: Personal bibliographies
and: SICRIS
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