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  • Toxicity and clinical results after proton therapy for pediatric medulloblastoma [Elektronski vir] : a multi-centric retrospective study
    Ruggi, Alessandro ...
    Medulloblastoma is the most common malignant brain tumor in children. Even if current treatment dramatically improves the prognosis, survivors often develop long-term treatment-related sequelae. The ... current radiotherapy standard for medulloblastoma is craniospinal irradiation with a boost to the primary tumor site and to any metastatic sites. Proton therapy (PT) has similar efficacy compared to traditional photon-based radiotherapy but might achieve lower toxicity rates. We report on our multi-centric experience with 43 children with medulloblastoma (median age at diagnosis 8.7 years, IQR 6.6, M/F 23/20; 26 high-risk, 14 standard-risk, 3 ex-infant), who received active scanning PT between 2015 and 2021, with a focus on PT-related acute-subacute toxicity, as well as some preliminary data on late toxicity. Most acute toxicities were mild and manageable with supportive therapy. Hematological toxicity was limited, even among HR patients who underwent hematopoietic stem-cell transplantation before PT. Preliminary data on late sequelae were also encouraging, although a longer follow-up is needed.
    Source: Cancers [Elektronski vir]. - ISSN 2072-6694 (Vol. 14, iss. 11, 2022, str. 2747-1-2747-11)
    Type of material - e-article
    Publish date - 2022
    Language - english
    COBISS.SI-ID - 110825219

    Link(s):

    https://www.mdpi.com/2072-6694/14/11/2747/pdf
    DOI

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