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Sensitive liquid chromatography-tandem mass spectrometry method for determination of hydrochlorothiazide in human plasma
Slavec, Marija, 1977- ; Merslavič, Mateja
A sensitive and specific analytical method for hydrochlorothiazide (HCT) in human plasma has been developed, included liquid-liquid extraction procedure followed by high performance liquid ...chromatographic separation with tandem mass spectrometric detection (LC-MS/MS). The method is suitable for quantification of HCT in plasma samples in concentration range 2-200 ng/ml. The method was used for the determination of hydrochlorothiazide in bioequivalnce study.
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