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Single and combined potential of polystyrene microparticles and fluoranthene in the induction of DNA damage in haemocytes of Mediterranean mussel (Mytilus galloprovincialis)Kolarević, Stoimir ...In this study, the possible ‘vector effect’ within the exposure of Mediterranean mussels (Mytilus galloprovincialis) to polystyrene microplastics with adsorbed fluoranthene was investigated by ... applying the multibiomarker approach. The major focus was placed on genotoxicological endpoints as to our knowledge there are no literature data on the genotoxicity of polystyrene microparticles alone or with adsorbed fluoranthene in the selected experimental organisms. DNA damage was assessed in haemocytes by comet assay and micronucleus test. For the assessment of neurotoxicity, acetylcholinesterase activity was measured in gills. Glutathione S-transferase was assessed in gills and hepatopancreas since these enzymes are induced for biotransformation and excretion of lipophilic compounds such as hydrocarbons. Finally, differences in physiological response within the exposure to polystyrene particles, fluoranthene, or particles with adsorbed fluoranthene were assessed by the variation of heart rate patterns studied by the noninvasive laser fibre-optic method. The uniform response of individual biomarkers within the exposure groups was not recorded. There was no clear pattern in variation of acetylcholinesterase or glutathione S-transferase activity which could be attributed to the treatment. Exposure to polystyrene increased DNA damage which was detected by the comet assay but was not confirmed by micronucleus formation. Data of genotoxicity assays indicated differential responses among the groups exposed to fluoranthene alone and fluoranthene adsorbed to polystyrene. Change in the heart rate patterns within the studied groups supports the concept of the Trojan horse effect within the exposure to polystyrene particles with adsorbed fluoranthene.Source: Mutagenesis. - ISSN 0267-8357 (Vol. 38, iss. 1, Jan. 2023, str. 3-12)Type of material - article, component part ; adult, seriousPublish date - 2023Language - englishCOBISS.SI-ID - 121611779
Author
Kolarević, Stoimir |
Kračun-Kolarević, Margareta |
Jovanović Marić, Jovana |
Djordjević, Jelena, mikrobiologinja |
Vuković-Gačić, Branka |
Joksimović, Danijela |
Martinović, Rajko |
Bajt, Oliver |
Ramšak, Andreja, 1966-
Topics
microplastics |
fuoranthene |
polystyrene |
genotoxicity |
Mytilus galloprovincialis |
comet assay
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Kolarević, Stoimir | ![]() |
Kračun-Kolarević, Margareta | ![]() |
Jovanović Marić, Jovana | ![]() |
Djordjević, Jelena, mikrobiologinja | ![]() |
Vuković-Gačić, Branka | ![]() |
Joksimović, Danijela | ![]() |
Martinović, Rajko | ![]() |
Bajt, Oliver | 04650 |
Ramšak, Andreja, 1966- | 15367 |
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