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Subungual osteogenic malignant melanoma : a case reportGolouh, Rastko ; Zidar, AndrejaOsteogenic melanoma may mimic many other, especially osteogenic sarcoma; only 12 cases have been reported so far. To characterize this unusual neoplasm further, we present the clinicopathologic ... findings of a new case. A 67-year-old woman was treated unsuccessfully for "fungal granuloma" of her great toe. After nail ablation and incisiional biopsy, the toe was exarticulated. Histologically, we found a high-grade, spindle, focally epithelioid, amelanotic malignant tumor with a distinct osteoid and chondroid matrix. Spindle, epithelioid, osteoblastic, and chondroblastic tumor cells were immunoreactive for vimentin, S-100 protein, and NKI/C3. Ultrastructurally, diagnostic premelanosomes were not identified. Features that support a diagnosis of osteogenic melanoma are superficial subungual location, absence of bone involvement, and immunoreactivity for vimentin, S-100 protein, and NKI/C3. The unusual features of current tumor are absence of radial growth phase, negative reaction to HMB-45, and ultrastructural absence of melanosomes.Source: International journal of surgical pathology. - ISSN 1066-8969 (Letn. 4, št. 4, 1997, str. 249-254)Type of material - article, component partPublish date - 1997Language - englishCOBISS.SI-ID - 12167897
Author
Golouh, Rastko |
Zidar, Andreja
Topics
Melanoma |
Pathology |
Toes |
Osteoblasts |
Immunohistochemistry |
Microscopy, electron
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source: International journal of surgical pathology. - ISSN 1066-8969 (Letn. 4, št. 4, 1997, str. 249-254)
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Zidar, Andreja | 02747 |
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