Akademska digitalna zbirka SLovenije - logo
ALL libraries (COBIB.SI union bibliographic/catalogue database)
  • Molecular and pro-inflammatory aspects of COVID-19 [Elektronski vir] : the impact on cardiometabolic health
    LoPresti, Elena ...
    Obesity, type 2 diabetes (T2DM), hypertension (HTN), and Cardiovascular Disease (CVD) often cluster together as “Cardiometabolic Disease” (CMD). Just under 50 % of patients with CMD increased the ... risk of morbidity and mortality right from the beginning of the COVID-19 pandemic as it has been reported in most countries affected by the Sars-CoV2 virus. One of the pathophysiological hallmarks of COVID-19 is the overactivation of the immune system with a prominent IL-6 response, resulting in severe and systemic damage involving also cytokines such as IL2, IL4, IL8, IL10, and interferon-gamma were considered strong predictors of COVID-19 severity. Thus, in this mini-review, we try to describe the inflammatory state, the alteration of the adipokine profile, and cytokine production in the obese state of infected and not infected by SARS-CoV2 patients with the final aim to find possible influences of COVID-19 on CMD and CVD. The immunological-based discussion of the molecular processes could inspire the study of promising targets for managing CMD patients and its complications during COVID-19.
    Source: Biochimica et biophysica acta. Molecular basis of disease.. - ISSN 1879-260X (Vol. 1868, iss. 12, Dec. 2022, str. 1-8)
    Type of material - e-article ; adult, serious
    Publish date - 2022
    Language - english
    COBISS.SI-ID - 123412995

    Link(s):

    https://www.sciencedirect.com/science/article/pii/S0925443922002307
    DOI

Shelf entry