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  • Oxygen delivery-consumption relationship in adult respiratory distress syndrome patients : the effects of sepsis
    Špec-Marn, Ana ...
    The oxygen consumption-delivery relationship (VO2/DO2) was studied in 15 sedated paralyzed patients with the adult respiratory distress syndrome (ARDS)due to multiple trauma and in whom sepsis was ... absent. Different levels (0 to 15 cm H2O) of positive end-expiratory pressure (PEEP) were applied. Oxygen delivery was calculated from cardiac index (thermodilution technique) and arterial oxygen content measurements. Oxygen consumption was calculated using Fick's equation. Regression lines were obtained for each patient. Oxygensupply dependency was defined as a significant (P < .05) relationship between changes in VO2 and DO2 with PEEP. Results were compared with those obtained in 18 ARDS patients in whom ARDS was due to sepsis. In nonseptic ARDSpatients no significant relationship between changes in VO2 and DO2 with PEEP was found within the experimental range of DO2 on zero end-expiratory pressure (ZEEP) (347 to 845 mL/min/m2). None of these patients had multiple organ system failure (MOSF), and 73% survived. In ARDSpatients in whom sepsis was present, supply dependency was present only when DO2 on ZEEP ranged between 330 and 640 mL/min/m2. All these patients developed MOSF and died. When DO2 on ZEEP ranged between 686 and 951 mL/min/m2 in septic ARDS patients,the supply dependency phenomenon was absent and only three patients developed MOSF and died (70% survivors). In almost all patients PEEP reduced DO2 and therefore worsened O2 balance by either increasing O2 extraction ratioand approaching the critical threshold for supply dependency or dismissing DO2 from the range of non-supply dependency.
    Source: Journal of critical care. - ISSN 0883-9441 (Letn. 8, št. 1, 1993, str. 43-50)
    Type of material - article, component part
    Publish date - 1993
    Language - english
    COBISS.SI-ID - 13350617

source: Journal of critical care. - ISSN 0883-9441 (Letn. 8, št. 1, 1993, str. 43-50)
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