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Synchronous herpes simplex virus and cytomegalovirus esophagitisVodovnik, Aleksandar ; Cerar, Anton, 1945-Infective esophagitis is a rare disease, affecting mostly immunocompromised patients. Very few cases of a multiple viral infection have been reported. We present a case of combined cytomegalovirus ... (CMV) and herpes simplex virus (HSV) esophagitis in an 81-year-old female with extracapillary sclerosing glomerulonephritis treated for five months with steroids and chemotherapy. Shedied of septic shock. At autopsy, erosive and ulcerative esophagitis was found in the distal half of the esophagus. Slides were stained by HE, and the immunohistochemical avidin-biotin method was used to detect HSV and CMV infection. On histological examination of the esophagus, epithelial giant cells with intranuclear viral inclusions showing HSV immunopositivity were found at the margin of the ulcerations. Giant cells with intranuclear inclusions with CMV immunopositivity were also found in the mesenchymal cells obtained from the ulcer bed. Long-term immunosuppressive therapy provoked an immune deficiency, evidenced by grave leukopenia and depletion of all bone marrow elements. Diagnosis of HSV and CMV esophagitis is important to evaluatethe risk of hemorrhage and esophageal perforation in esophagitis.Source: Zeitschrift für Gastroenterologie. - ISSN 0044-2771 (Letn. 38, št. 6, 2000, str. 491-494)Type of material - article, component partPublish date - 2000Language - englishCOBISS.SI-ID - 14008793
Author
Vodovnik, Aleksandar |
Cerar, Anton, 1945-
Topics
Cytomegalovirus infections |
Diagnosis |
Pathology |
Esophagitis |
Diagnosis |
Pathology |
Herpes simplex |
Diagnosis |
Pathology |
Opportunistic infections |
Diagnosis |
Pathology |
Aged, 80 and over |
Cyclophosphamide |
Adverse effects |
Therapeutic use |
Diagnosis, differential |
Drug therapy, combination |
Esophagus |
Pathology |
Glomerulosclerosis, focal |
Drug therapy |
Immunoenzyme techniques |
Immunosuppressive agents |
Adverse effects |
Therapeutic use |
Inclusion bodies |
Methylprednisolone |
Therapeutic use |
Adverse effects |
Ezofagitis |
Herpes simplex |
Oportunistične infekcije |
Ciklofosfamid |
Diagnostika |
Ezofagus |
Glomerulonefritis |
Citomegalovirus, okužbe |
Imunoencimske tehnike |
Imunosupresivi |
Inkluzijska telesca |
Metilprednisolon |
Ostareli |
Zdravilo, terapija sestavljena
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Vodovnik, Aleksandar | 15471 |
Cerar, Anton, 1945- | 05367 |
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