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Funkcionalna androgenizacija = Functional hyperandrogenismLegan, Mateja ; Kocijančič, Andreja, 1942-2021Functional hyperandrogenism is common endocrinological disorder of premenopausal women characterized by hyperandrogenism, hirsutism with or without androgenic alopecia and chronic anovulation. The ... controversy regardingthe pathophysiological mechanism underlying the disease still persists. Insulin resistance and hyperinsulinism are now well recognized features of obese women with functional hyperandrogenism and accepted pathogenetic factor of disorder in obese patients. Insulin enhances lutheotropic hormone secretion and together with it promotes synthesis of androgens in ovaries. Insulin affects the degree of free androgens by loweringserum concentrations of sex-hormone binding globuline. It stimulates synthesis of androgens in adrenal glands and ovaries by enhancing activity of citocrom P450c17alpha. Non-obese women with functional hyperandrogenism have less expressed insulin resistance and higher serum growth hormone concentrations than obese androgenized women as well as weight matched contiols. Higher growth hormone directly and indirectly (through insulin-like growth factor-i) influence ovarian cells end stimulates androgen synthesis: There is possible link between both known aethiopathogenetic factors of functional hyperandrogenism: growth hormone induces insulin resistance and hyperinsulinaemia, which in turn sensitate peripheral tissues for growth hormone.Source: Medicinski razgledi : [medicinski pregledni, strokovni in raziskovalni članki]. - ISSN 0025-8121 (Letn. 40, št. 2, september 2001, str. 183-189)Type of material - article, component partPublish date - 2001Language - slovenianCOBISS.SI-ID - 14313945
Author
Legan, Mateja |
Kocijančič, Andreja, 1942-2021
Topics
Hyperandrogenism |
Etiology |
Hirsutism |
Insulin resistance |
Hyperinsulinemia |
Estrone |
Somatotropin |
Hiperandrogenizem |
Hiperinzulinemija |
Hirzutizem |
Insulinska rezistenca |
Estron |
Somatotropin
source: Medicinski razgledi : [medicinski pregledni, strokovni in raziskovalni članki]. - ISSN 0025-8121 (Letn. 40, št. 2, september 2001, str. 183-189)
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Legan, Mateja | 12888 |
Kocijančič, Andreja, 1942-2021 | 03343 |
Source: Personal bibliographies
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