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Body, heart, thyroid gland and skeletal muscle weight changes in rats with altered thyroid statusSoukup, Tomáš ...In the present paper we describe changes of anatomical parameters in inbred Lewis strain rats, namely their body weight, body weight gain per week, absolute and relative heart, thyroid gland and ... skeletal muscle weights, that are assumed to reflect experimentally altered thyroid status. The hyperthyroidstate was induced by DL-thyroxine or Na 3,3',5-triiodo-L-thyronine, while methimazole was employed for inducing hypothyroidism. We have found that when compared to euthyroid rats, hypothyroidism resulted in a significantly lower body weight gain, absolute and relative heart weight and, in contrast, in a significant increase of absolute and relative thyroid gland weight. On the other hand, hyperthyroidismled to a significant increase of absolute and relative heart weight and to a significant eduction of absolute and relative thyroid gland weight. However, the body mass was not significantly altered in hyperthyroidism as compared with euthyroid rats. We conclude that our protocolleads to chronic hyper- or hypothyroidism as demonstrated by body, heart and thyroid gland weight changes. These anatomical data can thus be utilized as supplemental criteria for the assessment of the thyroid state of experimental rats.Source: Physiological research. - ISSN 0862-8408 (Letn. 50, št. 6, 2001, str. 619-626)Type of material - article, component partPublish date - 2001Language - englishCOBISS.SI-ID - 14534361
Author
Soukup, Tomáš |
Zachařová, Gisela |
Smerdu, Vika |
Jirmanova, I...
Topics
Body weight |
Organ weight |
Heart |
Thyroid gland |
Muscle, skeletal |
Hypothyroidism |
Chemically induced |
Hyperthyroidism |
Chemically induced |
Weight gain |
Rats, inbred lew |
Levothyroxine |
Dextrothyroxine |
Methimazole |
Mišica skeletna |
Srce |
Teža organa |
Telesna teža |
Ščitnica |
Dekstrotiroksin |
Hipertiroidizem |
Hipotiroidizem |
Metimazol |
Miši seva Lew |
Teža, pridobivanje |
levotiroksin
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Soukup, Tomáš | |
Zachařová, Gisela | |
Smerdu, Vika | 10641 |
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