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  • Multilayer methacrylate-based wound dressing as a therapeutic tool for targeted pain relief [Elektronski vir]
    Zidarič, Tanja, 1987- ...
    This study presents an innovative wound dressing system that offers a highly effective therapeutic solution for treating painful wounds. By incorporating the widely used non-steroidal ... anti-inflammatory drug diclofenac, we have created an active wound dressing that can provide targeted pain relief with ease. The drug was embedded within a biocompatible matrix composed of polyhydroxyethyl methacrylate and polyhydroxypropyl methacrylate. The multilayer structure of the dressing, which allows for sustained drug release and an exact application, was achieved through the layer-by-layer coating technique and the inclusion of superparamagnetic iron platinum nanoparticles. The multilayered dressings’ physicochemical, structural, and morphological properties were characterised using various methods. The synergistic effect of the incorporated drug molecules and superparamagnetic nanoparticles on the surface roughness and release kinetics resulted in controlled drug release. In addition, the proposed multilayer wound dressings were found to be biocompatible with human skin fibroblasts. Our findings suggest that the developed wound dressing system can contribute to tailored therapeutic strategies for local pain relief.
    Source: Materials [Elektronski vir]. - ISSN 1996-1944 (Vol. 16, issue 6, [article no.] 2361, 2023, str. 1-21)
    Type of material - e-article
    Publish date - 2023
    Language - english
    COBISS.SI-ID - 146598147

    Link(s):

    https://www.mdpi.com/1996-1944/16/6/2361
    Digital Library of the University of Maribor – DLUM
    DOI

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