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K(ATP) channel activation reduces the severity of postresuscitation myocardialdysfunctionTang, Wanchung ...Postresuscitation myocardial dysfunction has been recognized as a leading cause of the high postresuscitation mortality rate. We investigated the effects of ischemic preconditioning and activation of ... ATP-sensitive K(+) (K(ATP)) channels on postresuscitation myocardial function. Ventricular fibrillation (VF) was induced in 25 Sprague-Dawley rats. Cardiopulmonary resuscitation (CPR), including mechanical ventilation and precordial compression, was initiated after 4 min of untreated VF. Defibrillation was attempted after 6 min of CPR. The animals were randomized to five groups treated with 1) ischemic preconditioning, 2) K(ATP) channel opener, 3) ischemic preconditioning with K(ATP) channel blocker administered 1 min after VF, 4) K(ATP) channel blocker administered 45 min before induction of ischemicpreconditioning, and 5) placebo. Postresuscitation myocardial function, as measured by the rate of left ventricular pressure increase at 40 mmHg, the rate of left ventricular decline, cardiac index, and duration of survival, was significantly improved in both preconditioned and K(ATP) channelopener-treated animals. K(ATP) channel blocker administered 45 min before induction of ischemic preconditioning completely abolished the myocardial protective effects of preconditioning. We conclude that ischemic preconditioning significantly improved post-CPR myocardial function and survival. These results also provide evidence that the myocardial protective effects of ischemic preconditioning are mediated by K(ATP) channel activation.Source: American journal of physiology. heart and circulatory physiology. - ISSN 0363-6135 (Letn. 279, št. 4, 2000, str. H1609-15)Type of material - article, component partPublish date - 2000Language - englishCOBISS.SI-ID - 14881497
Author
Tang, Wanchung |
Weil, Max Harry |
Sun, Shijie |
Pernat, Andrej |
Mason, Earl
Topics
Potassium channels |
Heart |
Physiopathology |
Adenosine triphosphate |
Survival analysis |
Rats, sprague-dawley |
Perfusion |
Ischemic preconditioning, myocardial |
Incidence |
Glyburide |
Therapeutic use |
Coronary circulation |
Cardiac complexes, premature |
Epidemiology |
Blood pressure |
Drug effects |
Antihypertensive agents |
Therapeutic use |
Adenozin trifosfat |
Kalijevi kanalčki |
Srce |
Analiza preživetja |
Antihipertenzivi |
Gliburid |
Incidenca |
Ishemična predstopnja miokardna |
Koronarna cirkulacija |
Krvni pritisk |
Perfuzija |
Podgane, Sprague-Dawley |
Srce, kompleksi prezgodnji
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Pernat, Andrej | 14882 |
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