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  • Vpliv genetske variabilnosti v poteh homologne rekombinacije na odgovor na zdravljenje z obsevanjem pri raku dojk = Genetic variability of homologous recombination repair genes and radiotherapy outcome in breast cancer patients
    Dugar, Franja ...
    Breast cancer is a heterogeneous disease that can be treated by surgery, systemic therapy, and radiotherapy. Adjuvant breast cancer radiotherapy has important implications for patient survival but ... also causes adverse events. During radiation, not only cancer cells are irradiated, but also normal cells of surrounding tissues. The degree of adverse events after radiotherapy varies among patients with the same treatment scheme, which could be a result of genetic variability. Radiation causes both tumour cell DNA damage and tumour cell death. The double-strand break is the most harmful type of DNA damage following radiation, which can be repaired by homologous recombination. Genetic variability of genes encoding DNA repair proteins can affect their expression and function, which could furthermore impact the degree of successful DNA repair and consequently also radiotherapy outcome.
    Source: Zdravniški vestnik : glasilo Slovenskega zdravniškega društva = Slovenian medical journal = journal of Slovenian Medical Association. - ISSN 1318-0347 (Letn. 92, št. 3/4, 2023, str. 182-190)
    Type of material - article, component part ; adult, serious
    Publish date - 2023
    Language - slovenian
    COBISS.SI-ID - 149942275

    Link(s):

    https://vestnik.szd.si/index.php/ZdravVest/article/view/3370/4018
    DOI

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