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Comparison of short- and long-term effectiveness between anti-TNF and ustekinumab after vedolizumab failure as first-line therapy in crohn’s disease [Elektronski vir] : a multi-center retrospective cohort studyAlbshesh, Ahmad ...Background: The effectiveness of anti-TNF or ustekinumab (UST) as a second-line biologic after vedolizumab (VDZ) failure has not yet been described. Aims and methods: In this retrospective ... multicenter cohort study, We aim to investigate the effectiveness of anti-TNF and UST as second-line therapy in patients with Crohn's disease (CD) who failed VDZ as a first-line treatment. The primary outcome was clinical response at week 16-22. Secondary outcomes included the rates of clinical remission, steroid-free clinical remission, CRP normalization, and adverse events. Results: Fifty-nine patients who failed on VDZ as a first-line treatment for CD were included; 52.8% patients received anti-TNF and 47.2% UST as a second-line therapy. In initial period (Week 16-22), the clinical response and remission rate was similar between both groups: 61.2% vs. 68%, p = 0.8 and 48.3% vs. 56%, p = 0.8 on anti-TNF and UST therapy, respectively. Furthermore, in the maintenance period the rate was similar: 75% vs. 82.3%, p = 0.8 and 62.5% vs. 70.5%, p = 0.8, respectively. Of the patients, 12 out of the 59 stopped the therapy, without a significant difference between the two groups (p = 0.6). Conclusion: Second-line biological therapy after VDZ failure therapy was effective in >60% of the patients with CD. No differences in effectiveness were detected between the use of anti-TNF and UST as a second line.Source: Journal of clinical medicine [Elektronski vir]. - ISSN 2077-0383 (Vol. 12, iss. 7, [article no.] 2503, 2023, str. 1-10)Type of material - e-articlePublish date - 2023Language - englishCOBISS.SI-ID - 150671107
Author
Albshesh, Ahmad |
Bannon, Lian |
Sharar Fischer, Tali |
Truyens, Marie |
Vavricka, Stephan R. |
Tepeš, Katja |
Pugliese, Daniela |
Savarino, Eduardo V. |
Zittan, Eran |
Drobne, David, 1978-
Topics
Crohn’s disease |
anti-TNF |
drug positioning |
treatment failure |
treatment response |
ustekinumab |
vedolizumab |
Crohnova bolezen |
anti-TNF |
pozicioniranje zdravil |
neuspeh zdravljenja |
odziv na zdravljenje |
ustekinumab |
vedolizumab
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Albshesh, Ahmad | ![]() |
Bannon, Lian | ![]() |
Sharar Fischer, Tali | ![]() |
Truyens, Marie | ![]() |
Vavricka, Stephan R. | ![]() |
Tepeš, Katja | 37796 |
Pugliese, Daniela | ![]() |
Savarino, Eduardo V. | ![]() |
Zittan, Eran | ![]() |
Drobne, David, 1978- | 38327 |
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