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Estrogenic potency of endocrine disrupting chemicals and their mixtures detected in environmental waters and wastewatersDurcik, Martina ...Endocrine disrupting chemicals such as natural and synthetic steroid hormones and bisphenols are among the most important pollutants in the aquatic environment. We performed an environmental chemical ... analysis of five Slovenian water samples, two rivers, one groundwater, and the influent and effluent of wastewater treatment plants, with a highly sensitive analysis of twenty-five endocrine-disrupting compounds belonging to the groups of natural hormones, synthetic hormones, and bisphenols. Since these compounds are simultaneously present in the environment, it is important to study their individual effects as well as the effects of mixtures. We investigated in vitro the estrogenic potency of selected natural and synthetic steroid hormones and bisphenols detected in surface, ground and waste water in Slovenia using the OECD-validated transactivation assay on the cell line Hela9903. We predicted their mixture effects using the concentration addition model and compared them with experimentally determined values. Two mixing designs were used: a balanced design in which chemicals were combined in proportion to their individual EC50 values, and an unbalanced design with compounds in proportion to their measured concentrations in the environmental samples. The estrogenic effects of the experimental mixtures followed the concentration addition model. Real water samples exhibited weaker estrogenic effects, showing the great heterogeneity of the real water samples.Source: Chemosphere. - ISSN 0045-6535 (Vol. 330, 2023, 13 str.)Type of material - article, component part ; adult, seriousPublish date - 2023Language - englishCOBISS.SI-ID - 150677507
Author
Durcik, Martina |
Grobin, Andrej |
Roškar, Robert, 1975- |
Trontelj, Jurij |
Peterlin-Mašič, Lucija
Topics
Hormonski motilci |
Estrogeni |
bisphenols |
concentration addition |
environmental water |
estrogenic activity |
hormones |
mixtures |
bisfenoli |
dodatek koncentracij |
okoljska voda |
estrogena aktivnost |
hormoni |
mešanice
Author | Durcik, Martina ... |
Title | Estrogenic potency of endocrine disrupting chemicals and their mixtures detected in environmental waters and wastewaters |
Publication date | |
COBISS.SI-ID | 150677507 |
Publication version in repository | Publisher's version |
Publication licence | Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International |
Embargo | Immediate publication for public |
Project(s) from which the publication was funded
Title | Acronym | Project ID | Funder |
---|---|---|---|
Farmacevtska kemija: načrtovanje, sinteza in vrednotenje učinkovin | P1-0208-2022 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
|
Farmacevtska tehnologija: od dostavnih sistemov učinkovin do terapijskih izidov zdravil pri otrocih in starostnikih | P1-0189-2018 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
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Link |
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https://www.sciencedirect.com/science/article/pii/S0045653523009797 |
https://repozitorij.uni-lj.si/IzpisGradiva.php?id=145648 |
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Durcik, Martina | 50490 |
Grobin, Andrej | 52093 |
Roškar, Robert, 1975- | 23549 |
Trontelj, Jurij | 23420 |
Peterlin-Mašič, Lucija | 19317 |
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