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A new approach to separation of voltage-activated Ca currents in rat melanotrophsKocmur, Laura ; Zorec, Robert, 1958-The whole cell patch clamp technique was used to study voltage-activated calcium currents in rat melanotrophs. Voltage ramps of the same amplitude and of different durations were applied to separate ... Ca currents with different electrophysiological properties. The application of those with voltage gradient of 0.5 V/s resulted in a clear separation of two inward current components, activated at -55 +/- 5 mV and -24 +/- 5 mV respectively, corresponding to low (LVA) and high (HVA) voltage-activated currents. The proportion of cells displaying such current separation was reduced either at voltage gradients of 0.053 V/s or 1.6 V/s. The application of nitrendipine andnicardipine resulted in a blockage of both currents, where the HVA current component was more sensitive to the agents. The sensitivity of both Ca currents to dihydropyridine antagonists suggests that these currents may be mediated by subtypes of a dihydropyridine sensitive Ca channel.Source: Pflügers Archiv : european journal of physiology. - ISSN 0031-6768 (Let. 425, št. 1-2, 1993, str. 172-174)Type of material - article, component partPublish date - 1993Language - englishCOBISS.SI-ID - 151001
Author
Kocmur, Laura |
Zorec, Robert, 1958-
Topics
Calcium channels |
Isolation and purification |
Msh |
Metabolism |
Pituitary gland |
Chemistry |
Calcium channels |
Physiology |
Dihydropyridines |
Pharmacology |
Electric conductivity |
Electric stimulation |
Nicardipine |
Pharmacology |
Nitrendipine |
Pharmacology |
Pituitary gland |
Cytology |
Physiology |
Rats |
Rats, wistar |
Animal |
Male |
Rats
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Database name | Field | Year |
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Kocmur, Laura | 12438 |
Zorec, Robert, 1958- | 03702 |
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