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Lack of suitability of the rabbit model for particulare uterine artery embolizationBinkert, Christoph A. ...Purpose: The goal of this study was to evaluate the rabbit model for studies of particulate uterine artery embolization (UAE). Rabbits were chosen because it was believed that their year-round ... breeding time and short duration of pregnancy would be useful in studies of fertility and pregnancy after UAE. Materials and methods: Bilateral UAE was performed in 12 adult female New Zealand White rabbits weighing 4-5.2 kg. All animals were proven to be breeders before treatment. Each uterine artery was embolized to stasis with use of 180-300-micro m polyvinyl alcohol (PVA) particles (n = 9 animals), 500-710-micro m PVA particles (n = 1), or tris-acryl 500-700-micro m gelatin microspheres (n = 2). Result: Two rabbits died 7 days after embolization and the other 10 rabbits had to be killed because of malaise and weight loss 4-8 dalfter embolization. In all animals, necropsy demonstrated extensive uterine necrosis sparing only the tip of the uterine horn. Conclusion: Rabbits are an unsuitable model for studies of UAE with the embolic agents in clinical use.Source: Journal of vascular and interventional radiology [Elektronski vir]. - ISSN 1051-0443 (Letn. 13, št. 6, 2002, str. 609-612)Type of material - article, component partPublish date - 2002Language - englishCOBISS.SI-ID - 15334617
Author
Binkert, Christoph A. |
Andrews, Robert T. |
Pavčnik, Dušan, 1948-2019 |
Uchida, Barry |
Loriaux, Marc M. |
Toyota, Naoyuki |
Rösch, Josef
Topics
Uterine neoplasms |
Blood supply |
Embolization, therapeutic |
Leiomyoma |
Chemically induced |
Polyvinyl chloride |
Rabbits |
Disease models, animal |
Aortography |
Autopsy |
Embolizacija terapevtska |
Leiomiom |
Maternica, novotvorbe |
Polivinil klorid |
Aortografija |
Avtopsija |
Bolezen, živalski modeli |
Zajci
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Pavčnik, Dušan, 1948-2019 | 12718 |
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