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Basal glucose level as an independent predictor of fertilization rate in patients without polycystic ovary syndrome included in an in-vitro fertilization programSalobir, Boštjan, 1961- ...Insulin resistance is a common characteristic of women with polycystic ovary syndrome (PCOS) who are known to differ in their in-vitro fertilization outcomes compared to non-PCOS patients. As insulin ... resislance can be found in a considerable proportion of normal individuals, we assessed its contribution to ovarian responsiveness and fertilization rate. 26 non-PCOS pa bents undergoing IVF for the first time were investigated. Insulin resistance was evaluated by using a euglycemic hyperinsulinemic clamp technique. According tomultiple regression analysis insulin sensitivity, expressed as insulin stimulated glucose disposal rate, during euglycemic clamp (r =-0.81, p < 0.05 and r = -0.89; p < 0.01) and basal estradiol level (r=-0.54; p<0.05 and r=-0.56; p < 0.05) appeared significant negative predictors of the number of fertilized oocytes and embryos, respectively. Furthermore, basal glucose levelappeared independently as a significant positive predictor of the number of fertilized oocytes and the number of embryos. (r=0.90; p < 0.01 and r = 0.96; p < 0.01 respectively). We conclude that blood glucose concentration andinsulin resistance respectively are independent predictors of IVF outcome.Source: Wiener Klinische Wochenschrift. - ISSN 0043-5325 (Letn. 114, št. 12, 2002, str. 454-457)Type of material - article, component partPublish date - 2002Language - englishCOBISS.SI-ID - 15341273
Author
Salobir, Boštjan, 1961- |
Preželj, Janez |
Kocijančič, Andreja, 1942-2021 |
Meden-Vrtovec, Helena
Topics
Fertilization in vitro |
Insulin resistance |
Blood glucose |
Estradiol |
Insulin |
Glucose clamp technique |
Androstenedione |
Dehydroepiandrosterone sulfate |
LH |
FSH |
Estradiol |
Fertilizacija in vitro |
Insulinska rezistenca |
Inzulin |
Krvni sladkor |
Androstendion |
Dehidroepiandrosteron sulfat |
FSH |
Glukoza, zajetje, tehnika |
LH
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Salobir, Boštjan, 1961- | 00788 |
Preželj, Janez | 01989 |
Kocijančič, Andreja, 1942-2021 | 03343 |
Meden-Vrtovec, Helena | 08772 |
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