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Biokemična diagnoza feokromocitoma : kateri test je najboljši? = (Biochemical diagnosis of pheochromocytoma : which test is best?)Lenders, Jacques W.M. ...Izhodišče: Diagnozo feokromocitoma postavimo z biokemičnim dokazom tumorskega izločanja kateholaminov. Vendar še ni znano, kateri test je za postavitev diagnoze najboljši. Cllj: Določiti biokemični ... test ali kombinacijo testov, ki predstavlja najboljšo metodo za diagnosticiranje feokromocitoma. Oblika, mestoraziskave in bolniki: Multicentrična, kohortna raziskava bolnikov, testiranih za feokromocitom v 4 raziskovalnih centrih med letoma 1994 in 2001.Analiza je vključevala 214 bolnikov, pri katerih je bila potrjena diagnoza feokromocitoma, in 644 bolnikov, ki tumorja niso imeli. Vodilna merila izida: Občutljivost in specifičnost testa, krivulje ROC (receiver operating characteristic) ter pozitivne in negativne napovedne vrednosti pri različnih prevalencah pred testiranjem, z uporabo prostih metanefrinov v plazmi, plazemskih kateholaminov, kateholaminov v urinu, cefotnih in frakcioniranih metanefrinov v urinu in vanililmandljeve kisline v urinu. (Izvleček skrajšan pri 2000 znakih)Source: JAMA : the journal of the American Medical Association. - ISSN 1318-1092 (Letn. 10, št. 4, 2002, str. 247-254)Type of material - article, component partPublish date - 2002Language - slovenianCOBISS.SI-ID - 15346137
Author
Lenders, Jacques W.M. |
Pacak, Karel |
McClellan, Walther M. |
Linehan, Marston W. |
Mannelli, Massimo |
Friberg, Peter |
Keiser, Harry R. |
Goldstein, David S. |
Eisenhofer, Graeme
Other authors
Vipotnik-Vesnaver, Tina
Topics
Pheochromocytoma |
Diagnosis |
Metabolism |
Metanephrine |
Blood |
Catecholamines |
Metabolism |
Adrenal gland neoplasms |
Diagnosis |
Metabolism |
Sex factors |
Age factors |
Sensitivity and specificity |
Roc curve |
Predictive value of tests |
Cohort studies |
Feokromocitom |
Kateholamini |
Metanefrin |
Nadledvična žleza, novotvorbe |
Kohortne študije |
Napovedna vrednost testov |
Občutljivost in specifičnost |
ROK krivulja |
Spolni dejavniki |
Starostni faktorji
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