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Biokemična diagnoza feokromocitoma : kateri test je najboljši? = (Biochemical diagnosis of pheochromocytoma : which test is best?)
Lenders, Jacques W.M. ...
Izhodišče: Diagnozo feokromocitoma postavimo z biokemičnim dokazom tumorskega izločanja kateholaminov. Vendar še ni znano, kateri test je za postavitev diagnoze najboljši. Cllj: Določiti biokemični ...test ali kombinacijo testov, ki predstavlja najboljšo metodo za diagnosticiranje feokromocitoma. Oblika, mestoraziskave in bolniki: Multicentrična, kohortna raziskava bolnikov, testiranih za feokromocitom v 4 raziskovalnih centrih med letoma 1994 in 2001.Analiza je vključevala 214 bolnikov, pri katerih je bila potrjena diagnoza feokromocitoma, in 644 bolnikov, ki tumorja niso imeli. Vodilna merila izida: Občutljivost in specifičnost testa, krivulje ROC (receiver operating characteristic) ter pozitivne in negativne napovedne vrednosti pri različnih prevalencah pred testiranjem, z uporabo prostih metanefrinov v plazmi, plazemskih kateholaminov, kateholaminov v urinu, cefotnih in frakcioniranih metanefrinov v urinu in vanililmandljeve kisline v urinu. (Izvleček skrajšan pri 2000 znakih)
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