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  • Effect of airway surface liquid on the forces on the pharyngeal wall : experimental fluid-structure interaction study
    Pirnar, Jernej ; Širok, Brane ; Bombač, Andrej
    Obstructive sleep apnoea syndrome (OSAS) is a breathing disorder with a multifactorial etiology. The respiratory epithelium is lined with a thin layer of airway surface liquid preventing interactions ... between the airflow and epithelium. The effect of the liquid lining in OSAS pathogenesis remains poorly understood despite clinical research. Previous studies have shown that the physical properties of the airway surface liquid or altered stimulation of the airway mechanoreceptors could alleviate or intensify OSAS; however, these studies do not provide a clear physical interpretation. To study the forces transmitted from the airflow to the liquid-lined compliant wall and to discuss the effects of the airway surface liquid properties on the stimulation of the mechanoreceptors, a novel and simplified experimental system mimicking the upper airway fundamental characteristics (i.e., liquid-lined compliant wall and complex unsteady airflow features) was constructed. The fluctuating force on the compliant wall was reduced through a damping mechanism when the liquid film thickness and/or the viscosity were increased. Conversely, the liquid film damping was reduced when the surface tension decreased. Based on the experimental data, empirical correlations were developed to predict the damping potential of the liquid film. In the future, this will enable us to extend the existing computational fluid-structure interaction simulations of airflow in the human upper airway by incorporating the airway surface liquid effect without adopting two-phase flow interface tracking methods. Furthermore, the experimental system developed in this study could be used to investigate the fundamental principles of the complex once/twice-coupled physical phenomena.
    Source: Journal of biomechanics. - ISSN 0021-9290 (Vol. 63, Oct. 2017, str. 117-124)
    Type of material - article, component part ; adult, serious
    Publish date - 2017
    Language - english
    COBISS.SI-ID - 15693339

    Link(s):

    https://ac.els-cdn.com/S0021929017304256/1-s2.0-S0021929017304256-main.pdf?_tid=5675a9e4-ace7-11e7-bd92-00000aacb362&acdnat=1507549705_3545784e854ed245a0807ee62d15b40d
    DOI

source: Journal of biomechanics. - ISSN 0021-9290 (Vol. 63, Oct. 2017, str. 117-124)
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