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Cyclophosphamide metabolites perforate the apical plasma membranes of urothelial cells in ratsZupančič, Daša ; Jezernik, KristijanThe apical plasma membrane of differentiated superficial urothelial cells is characterised by the presence of asymmetric unit membrane (AUM). Cyclophosphamide (CP) metabolites cause perforation of ... these thickened membranes. In this study, apical plasma membranes were examined after CP injection by electron microscopy. The immediate effect of the CP metabolites was observed as small round holes appearing, first in the asymmetric apical plasma membrane of terminally differentiated superficial cells, and later in the symmetric apical plasma membrane of exposed undifferentiated intermediate and basal cells. Exposed cells which remained undamaged, immediately underwentmaturation of the symmetric apical plasma-membrane. These results indicate that CP metabolites perforate the symmetric and asymmetric membranes of most urothelial cells.Source: The International Conference on Life Sciences - 2001 : 22-26 September 2001, Gozd Martuljek, Slovenia : [proceedings] (Letn. 7, št. 1, 2002, str. 123-125)Type of material - conference contributionPublish date - 2002Language - englishCOBISS.SI-ID - 15693785
Author
Zupančič, Daša |
Jezernik, Kristijan
Topics
Cell Membrane |
Metabolism |
Ultrastructure |
Drug Effects |
Cell Membrane Permeability |
Drug Effects |
Cyclophosphamide |
Metabolism |
Pharmacology |
Urothelium |
Rats, Inbred F344 |
Time Factors |
Necrosis |
Microscopy, Electron |
Celična membrana |
Celična membrana, permeabilnost |
Ciklofosfamid |
Urotelij |
Mikroskopija elektronska |
Miši seva F344 |
Nekroza |
Časovni faktorji
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Database name | Field | Year |
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Zupančič, Daša | 20343 |
Jezernik, Kristijan | 05277 |
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