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Improved functional ability in patients with rheumatoid arthritis--longterm treatment with leflunomide versus sulfasalazineKalden, Joachim Robert ...Objective: We previously reported that the new disease modifying antirheumaticdrug leflunomide resulted in significant improvement in functional ability compared with placebo and sulfasalazine in a 6 ... month doubleblind, randomized, Phase III trial in rheumatoid arthritis (RA). The current study compared functional disability in cohorts of patients with RA from the initial study who volunteered to continue treatment with leflunomide or sulfasalazine. Methods: The Health Assessment Questionnaire (HAQ) was used to assess functional ability in patients completing 6 months of therapy who chose to continue in double blinded 12 and 24 month extensions. Patients on active regimens continued taking leflunomide 20 mg/day or sulfasalazine 2 g/day; those taking placebo were switched at Month 6 to sulfasalazine. Results: Leflunomide significantly improved patients' functional ability compared to placebo (p < or = 0.0001) and sulfasalazine (p < or = 0.01) at 6 months. These changes were seen as early as Month 1, and continued improvements were seen in 12 and 24 month cohorts. Mean HAQ scores were significantly improved with leflunomide compared with sulfasalazine at 24 months (-0.65 vs -0.36; p = 0.0149); corresponding changes in HAQ Disability Index (DI) were -0.73 vs -0.56 and were not statistically different. Leflunomide is safe and well tolerated and no unexpected adverse events were noted during the 2 year period; diarrhea, nausea, and alopecia were less frequent with continued treatment. Conclusion: These longterm data confirm leflunomide improves functional ability as shown by reductions in HAQ scores. The benefit of leflunomide is reflected in other efficacy criteria, such as global assessments and the American College of Rheumatology response rates, all of which showed significantly more improvement with leflunomide than sulfasalazine at 24 months.Source: Journal of rheumatology. - ISSN 0315-162X (Letn. 28, št. 9, 2001, str. 1983-1991)Type of material - article, component partPublish date - 2001Language - englishCOBISS.SI-ID - 16151257
Author
Kalden, Joachim Robert |
Scott, David L., 1951- |
Smolen, Josef S., 1950- |
Schattenkirchner, Manfred |
Rozman, Blaž, 1944- |
Williams, Bryan D. |
Kvien, Tore K. |
Jones, Peter, pred. managementa in trajnosti |
Williams, Richard B. |
Oed, Christine |
Rosenburg, Ronald
Other authors
European Leflunomide Study Group
Topics
Arthritis, Rheumatoid |
Drug Therapy |
Diagnosis |
Anti-Inflammatory Agents, Non-Steroidal |
Administration And Dosage |
Isoxazoles |
Administration And Dosage |
Sulfasalazine |
Administration And Dosage |
Age Factors |
Sex Factors |
Cohort Studies |
Double-Blind Method |
Drug Administration Schedule |
Long-Term Care |
Pain Measurement |
Patient Satisfaction |
Range Of Motion, Articular |
Severity Of Illness Index |
Time Factors |
Treatment Outcome |
Artritis revmatični |
Izoksazoli |
Protivnetna zdravila nesteroidna |
Sulfasalazin |
Bolečina, merjenje |
Bolnik, zadovoljstvo |
Dolgotrajna oskrba |
Dvojnoslepa metoda |
Indeks resnosti bolezni |
Kohortne študije |
Obseg gibov v sklepu |
Spolni faktorji |
Starostni faktorji |
Zdravilao, doziranje |
Zdravljenje, izid |
Časovni faktorji
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Kalden, Joachim Robert | |
Scott, David L., 1951- | |
Smolen, Josef S., 1950- | |
Schattenkirchner, Manfred | |
Rozman, Blaž, 1944- | 07180 |
Williams, Bryan D. | |
Kvien, Tore K. | |
Jones, Peter, pred. managementa in trajnosti | |
Williams, Richard B. | |
Oed, Christine | |
Rosenburg, Ronald |
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