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  • Detection of circulating tumor DNA by whole genome sequencing enables prediction of recurrence in stage III colorectal cancer patients with great inter-lab reproducibility [Elektronski vir]
    Frydendahl, Amanda ...
    Background: Detection of circulating tumor DNA (ctDNA) in plasma indicates the presence of cancer. In patients with very few copies of tumor DNA circulating in the blood, the blood sampling process ... becomes a potentially limiting factor. For ctDNA methods based on a single or a few genomic targets, it becomes stochastic whether the collected sample contains any tumor DNA fragments from targeted regions. To overcome this sampling limitation, we developed C2inform; a whole genome sequencing (WGS) approach, which detects ctDNA using a cumulative patient-specific signal from thousands of mutations throughout the entire genome. Aim: Here, we aim to I) evaluate the performance of C2inform in patients with UICC stage III colorectal cancer (CRC) using samples collected after the end of curatively intended treatment and serially during surveillance, II) assess the inter-lab reproducibility of C2inform and, III) investigate the potential for using the serial WGS data to track tumor genomic evolution in recurrence patients.
    Source: Proceedings of the 114th Annual Meeting of the American Association for Cancer Research [Elektronski vir] : Orlando, FL, Philadelphia (PA), April 14-19, 2023. Part A. Part B (1 spletni vir)
    Type of material - conference contribution ; adult, serious
    Publish date - 2023
    Language - english
    COBISS.SI-ID - 163628291

    Link(s):

    https://www.abstractsonline.com/pp8/#!/10828/presentation/4462

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