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Prothrombotic gene polymorphisms and atherothrombotic cerebral infarctionPetrovič, Danijel, 1963- ...Objectives: To test the hypothesis whether risk genotypes of the prothrombotic gene polymorphisms (I/D 4G5G PAI-1, G1691A factor V point mutation, factor VII Arg/Gln353) are risk factors for ACI in ... the Slovene population. The study sought an association between the insertion/deletion 4G/5G-plasminogen activator inhibitor 1 (PAI-1) gene polymorphism, the 1691G-A factor V point mutation or the arg353-to-gln factor VII gene polymorphism and atherothrombotic cerebral infarction (ACI). Material and methods: Ninety-six Slovene patients who suffered ACI were compared with 115 control subjects clinically free of cerebrovascular disease. Insertion/deletion 4G/5G PAI-1 gene polymorphism, 1691G-A factor V point mutation and arg353-to-gln polymorphism in the factor VII were determined using polymerase chain reaction. Results: The 4G4G genotype of 4G5G PAI-1 gene polymorphism was less frequent in cases (21.9%) than in controls (35.6%; OR = 0.5, 95% CI = 0.3-1; P = 0.033). No association was found either between the factor V point mutation (1691G-A) or the RR genotype of the factor VII Arg/Gln353 gene polymorphism and the risk of ACI using univariate analysis. Conclusion: The 4G/4G-PAI-1 genotype might be a protective factor against ACI, whereas the factor V point mutation (1691G-A) and the factor VII Arg/Gln353 gene polymorphism have not proved to be risk factors for ACI.Source: Acta Neurologica Scandinavica. - ISSN 0001-6314 (Vol. 108, no. 2, 2003, str. 109-113)Type of material - article, component part ; adult, seriousPublish date - 2003Language - englishCOBISS.SI-ID - 16420057
Author
Petrovič, Danijel, 1963- |
Milanez, Tomaž |
Kobal, Jan |
Bregar, Dejan |
Peterlin-Potisk, Karmen |
Peterlin, Borut, 1963-
Topics
Cerebral Infarction |
genetics |
Polymorphism (Genetics) |
Genotype |
Point Mutation |
Plasminogen Activator Inhibitor 1 |
genetics |
Promoter Regions (Genetics) |
Cerebral Arteriosclerosis |
Polymerase Chain Reaction |
Factor V |
Factor VII |
Genotip |
Možganski infarkt |
Plazminogen aktivator, inhibitor 1 |
Polimorfizem (genetika) |
Točkovna mutacija |
Faktor V |
Faktor VII |
Polimerazna, verižna reakcija |
Promoterska področja (genetika)
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Petrovič, Danijel, 1963- | 11252 |
Milanez, Tomaž | 16192 |
Kobal, Jan | 10693 |
Bregar, Dejan | 20471 |
Peterlin-Potisk, Karmen | 10466 |
Peterlin, Borut, 1963- | 10458 |
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