-
Redox status and telomere–telomerase system biomarkers in patients with acute myocardial infarction using a principal component analysis [Elektronski vir] : is there a link?Vukašinović, Aleksandra ...In the present study, we examined redox status parameters in arterial and venous blood samples, its potential to predict the prognosis of acute myocardial infarction (AMI) patients assessed through ... its impact on the comprehensive grading SYNTAX score, and its clinical accuracy. Potential connections between common blood biomarkers, biomarkers of redox status, leukocyte telomere length, and telomerase enzyme activity in the acute myocardial infarction burden were assessed using principal component analysis (PCA). This study included 92 patients with acute myocardial infarction. Significantly higher levels of advanced oxidation protein products (AOPP), superoxide anion (O2•−), ischemia-modified albumin (IMA), and significantly lower levels of total oxidant status (TOS) and total protein sulfhydryl (SH-) groups were found in arterial blood than in the peripheral venous blood samples, while biomarkers of the telomere–telomerase system did not show statistical significance in the two compared sample types (p = 0.834 and p = 0.419). To better understand the effect of the examined biomarkers in the AMI patients on SYNTAX score, those biomarkers were grouped using PCA, which merged them into the four the most contributing factors. The “cholesterol–protein factor” and “oxidative–telomere factor” were independent predictors of higher SYNTAX score (OR = 0.338, p = 0.008 and OR = 0.427, p = 0.035, respectively), while the ability to discriminate STEMI from non-STEMI patients had only the “oxidative–telomere factor” (AUC = 0.860, p = 0.008). The results show that traditional cardiovascular risk factors, i.e., high total cholesterol together with high total serum proteins and haemoglobin, are associated with severe disease progression in much the same way as a combination of redox biomarkers (pro-oxidant-antioxidant balance, total antioxidant status, IMA) and telomere length.Source: International journal of molecular sciences [Elektronski vir]. - ISSN 1422-0067 (Vol. 24, iss. 18, art. 14308, 2023, 12 str.)Type of material - e-article ; adult, seriousPublish date - 2023Language - englishCOBISS.SI-ID - 165104899
Author
Vukašinović, Aleksandra |
Klisic, Aleksandra |
Ostanek, Barbara, 1972- |
Kafedzic, Srdjan |
Zdravković, Marija |
Ilic, Ivan |
Sopić D., Miron |
Stefanović, Milica, kardiolog |
Bogavac Stanojević, Nataša |
Marc, Janja |
Nešković, Aleksandar |
Kotur Stevuljević, Jelena
Topics
Ateroskleroza |
Miokardni infarkt |
redoks stanje |
dolžina telomera |
novi biomarkerji |
atherosclerosis |
acute myocardial infarction |
redox status |
telomere length |
novel biomarkers
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Author | Vukašinović, Aleksandra ... |
Title | Redox status and telomere–telomerase system biomarkers in patients with acute myocardial infarction using a principal component analysis [Elektronski vir] : is there a link? |
Publication date | 2023-09-20 |
COBISS.SI-ID | 165104899 |
Publication version in repository | Publisher's version |
Publication licence | Creative Commons Attribution 4.0 International |
Embargo | Immediate publication for public |
Project(s) from which the publication was funded
Title | Acronym | Project ID | Funder |
---|---|---|---|
Ministry of Science, Technological Development and Innovation, Republic of Serbia | 451-03-47/2023-01/200161 |
Files that belong to the publication
Link |
---|
![]() |
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|---|
Vukašinović, Aleksandra | ![]() |
Klisic, Aleksandra | ![]() |
Ostanek, Barbara, 1972- | 18154 |
Kafedzic, Srdjan | ![]() |
Zdravković, Marija | ![]() |
Ilic, Ivan | ![]() |
Sopić D., Miron | ![]() |
Stefanović, Milica, kardiolog | ![]() |
Bogavac Stanojević, Nataša | ![]() |
Marc, Janja | 12189 |
Nešković, Aleksandar | ![]() |
Kotur Stevuljević, Jelena | ![]() |
Select pickup location:
Material pickup by post
Notification
Subject headings in COBISS General List of Subject Headings
Select pickup location
Pickup location | Material status | Reservation |
---|
Please wait a moment.