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Intraoperative electrochemotherapy of the posterior resection surface after pancreaticoduodenectomy : preliminary results of a hybrid approach treatment of pancreatic cancerČebron, Žan ...Despite extensive research in recent decades, pancreatic cancer continues to be among the most lethal forms of cancer, with no substantial increase in survival rates. Local recurrences account for ... approximately 30 per cent of all disease recurrences. With the intent to improve survival, we designed a novel, hybrid treatment strategy consisting of surgical resection and additional intraoperative electrochemotherapy of the posterior resection surface. We present the study protocols and preliminary findings of a prospective pilot study investigating this treatment approach. Methods Consenting patients with resectable pancreatic head ductal adenocarcinoma who met the inclusion criteria were enrolled in the study. After surgical resection, electrochemotherapy with bleomycin was performed using plate electrodes to cover the area between anatomical landmarks. Results Electrochemotherapy of the posterior resection surface was feasible in all 7 patients. We observed pancreatic fistula grade B in only one patient; all other noted complications were Clavien-Dindo grade 2 or less. The hospital mortality was 0%. Conclusions Our preliminary results suggest that a hybrid approach combining surgery with intraoperative electrochemotherapy is safe and feasible.Source: Bioelectrochemistry. - ISSN 1567-5394 (Vol. 155, 2024, str. 108576-1-108576-7)Type of material - article, component part ; adult, seriousPublish date - 2024Language - englishCOBISS.SI-ID - 165588227
Author
Čebron, Žan |
Djokić, Mihajlo |
Petrič, Miha, kirurg, 1981- |
Čemažar, Maja |
Omerzel, Maša, mag. farm. |
Serša, Gregor |
Trotovšek, Blaž
Topics
rak trebušne slinavke |
intraoperativna elektrokemoterapija |
elektroporacija |
pancreatic cancer |
intraoperative electrochemotherapy |
electroporation
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DRS, in which the journal is indexed
Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Čebron, Žan | 52586 |
Djokić, Mihajlo | 30463 |
Petrič, Miha, kirurg, 1981- | 51515 |
Čemažar, Maja | 14575 |
Omerzel, Maša, mag. farm. | 34373 |
Serša, Gregor | 08800 |
Trotovšek, Blaž | 15895 |
Source: Personal bibliographies
and: SICRIS
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