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Comparison of potential biological markers cathepsin B, cathepsin L, stefin A and stefin B with urokinase and plasminogen activator inhibitor-1 and clinicopathological data of breast carcinoma patientsLevičar, Nataša ...Cysteine, serine and metalloproteinases and their respective inhibitors are involved in tumor cell invasion and may have prognostic value for the outcome of malignant disease. The aim of the study ... was to compare the expression of new potential biological tumor markers, the lysosomal cysteine proteinases and their endogenous inhibitors, with that of the serine proteinases and their inhibitors in breast cancinoma and to relate their levels to the clinicopathological factors of the disease. Enzyme-linked immunosorbent assays (ELISAs) were used to measure cysteine cathepsin B (CatB) and cathepsin L (CatL) and their inhibitors, stefin A (StA)and stefin B (StB), together with urokinase (u-PA) and plasminogen activator inhibitor-1 (PAI-1), in 150 cytosols of primary invasive breast carcinoma. A good correlation was found between the levels of the two cysteine proteinases but only a moderate one between those of the cysteine and serine proteinases. u-PAand PAI-1 levels correlated positively with histological grade and negatively withestrogen receptor (ER) status. PAI-1 correlated with most clinicopathological factors that indicate the progression of the disease, while cathepsins and stefins were independent of these factors. In the total group of patients, high u-PA and PAI-1 and low StB levels correlated significantly with shorter disease-free survival (DFS), while CatB, CatL and StA did not. In lymph node negative patients, highCatB and CatL were also associated with shorter DFS, while u-PA remained the most significant of all these biological markers. In conclusion, this retrospective study showed u-PA to be of better prognostic relevance than the cysteine proteinases, though CatB and CatL were relevant for prognosis in lymph node negative breast cancer patients.Source: Cancer detection and prevention. - ISSN 0361-090X (Letn. 26, št. 1, 2002, str. 42-49)Type of material - article, component partPublish date - 2002Language - englishCOBISS.SI-ID - 16831783
Author
Levičar, Nataša |
Kos, Janko, 1959- |
Blejec, Andrej |
Golouh, Rastko |
Vrhovec, Ivan |
Frković Grazio, Snježana |
Lah Turnšek, Tamara
Topics
cathepsin B |
cathepsin L |
stefin A |
stefin B
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Levičar, Nataša | 17003 |
Kos, Janko, 1959- | 04648 |
Blejec, Andrej | 06989 |
Lah Turnšek, Tamara | 07802 |
Source: Personal bibliographies
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