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Preučevanje fizikalne stabilnosti fenofibrata v trdnih disperzijah z mezoporozno siliko kot nosilcem zdravilne učinkovine = Studying the physical stability of fenofibrate in solid dispersions with mesoporous silica as the drug carrierrsMatko, KlemenFenofibrat spada po biofarmacevtski klasifikaciji v razred II, kar pomeni, da je dobro permeabilen in slabo topen. Za izboljšanje biološke uporabnosti po peroralni aplikaciji, lahko uporabljamo ... pristope izboljševanja raztapljanja. Pri našem delu smo za ta namen izdelovali trdne disperzije, v katerih je nosilec učinkovine Syloid 244. Izdelali smo trdne disperzije s 50, 40, 30 in 20 % vsebnostjo fenofibrata in primerjali njegovo sproščanje. Ugotavljali smo kako uporaba različnih topil in različna temperatura odparevanja topila pri izdelavi trdne disperzije vpliva na njihove lastnosti. Vse trdne disperzije smo analizirali z diferenčno dinamično kalorimetrijo, s čimer smo ugotavljali ali je fenofibrat v amorfnem stanju. Disperzije smo postavili na enomesečno staranje pri temperaturi 40 °C in 75 % relativne vlažnosti zraka. Ponovno smo izvedli analizo s diferenčno dinamično kalorimetrijo in sproščali fenofibrat iz trdnih disperzij s 20 in 30 % vsebnostjo fenofibrata. Trdna disperzija s 30 % fenofibrata, ki je bila pripravljena v etil acetatu pri 93 °C, kaže najboljše lastnosti takoj po izdelavi in enomesečnem staranju. Iz nje smo s pomočjo granulata Avicel-a PH 101 in Syloid-a 244 stiskali tablete. Ugotovili smo, da se fenofibrat iz trdnih disperzij, ki so pripravljene z etil acetatom, bolje raztaplja kot iz tistih, ki so bile pripravljene z acetonom. Pri trdnih disperzijah, ki so pripravljene pri višji temperaturi, se fenofibrat bolje nalaga v pore Syloid-a, kar privede do manj sprememb s časom. Pri eksperimentalnem delu smo se odločili, da bomo pripravili po eno paralelko trdnih disperzij, saj so bili rezultati večinoma predvidljivi. Prihodnje raziskovanje se bo osredotočalo na bolj stabilne trdne disperzije. Da smo ohranili preglednost in se poglobili v analizo, smo se odločili, da izvedemo omejeno število eksperimentov, da naloga ne postane preobsežna.Type of material - master's thesis ; adult, seriousPublication and manufacture - Ljubljana : [K. Matko], 2023Language - slovenianCOBISS.SI-ID - 170045955
Author
Matko, Klemen
Other authors
Planinšek, Odon
Topics
Topnost |
fenofibrat |
trdne disperzije |
Syloid |
sproščanje učinkovin |
stabilnost učinkovin
Library/institution |
City | Acronym | For loan | Other holdings |
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Faculty of Pharmacy, Ljubljana | Ljubljana | FFALJ |
reading room 1 cop.
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Matko, Klemen | |
Planinšek, Odon | 14935 |
Source: Personal bibliographies
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