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Is chemotherapy alone adequate for young women with oestrogen-receptor-positive breast cancer?Aebi, S. ...Background: The prognosis of breast cancer in very young women is generally considered to be unfavourable. Therefore, the outcome of adjuvant therapy was analysed in a population of young (<35 years) ... premenopausal patients treated in four randomised controlled trials. Methods: Between 1978 and 1993 the International Breast Cancer Study Group (IBCSG) treated 3700 premenopausal andperimenopausal patients with various timing and duration of adjuvant cyclophosphamide, methotrexate, and fluorouracil (CMF with or without low-doseprednisone and oophorectomy). 314 of these women were less than 35 years old at randomisation. Findings: Relapse and death occurred earlier and more often in younger (<35 years) than in older (> or = 35) patients with a 10year disease-free survival of 35% (SE 3) versus 47% (1) (hazard ratio 1.41 š95% CI 1.22-1.62đ, p<0.001) and overall survival of 49% (3) versus 62% (1) (1.50 and 2 over black squaređ; š1 and 2 over black squaređ.28-1.77đ, p<0.001). Younger patients with oestrogen-receptor positive tumours had a significantly worse disease-free survival than younger patients with oestrogen-receptor negative tumours. By contrast, among older patients the disease-free survival was similar irrespective of oestrogen-receptor status. Interpretation: Young premenopausal breast cancer patients treated with adjuvant CMF chemotherapy had higher risk of relapse and death than older premenopausal patients, especially if their tumours expressed oestrogen receptors. The endocrine effects of chemotherapy alone are insufficient for the younger age group and these patients should strongly consider additional endocrine therapies (tamoxifen or ovarian ablation) if their tumours express oestrogen receptors.Source: The Lancet. - ISSN 0140-6736 (Letn. 355, št. 9218, May 2000, str. 1869-1874)Type of material - article, component partPublish date - 2000Language - englishCOBISS.SI-ID - 17403865
Author
Aebi, S. |
Lindtner, Jurij
Other authors
International Breast Cancer Study Group
Topics
Breast Neoplasms |
Drug Therapy |
Mortality |
Antineoplastic Agents, Combined |
Therapeutic Use |
Receptors, Estrogen |
Metabolism |
Age Factors |
Chemotherapy, Adjuvant |
Cyclophosphamide |
Administration And Dosage |
Disease-Free Survival |
Fluorouracil |
Administration And Dosage |
Multicenter Studies |
Ovariectomy |
Prednisone |
Administration And Dosage |
Premenopause |
Prognosis |
Randomized Controlled Trials |
Risk Factors |
Antineoplastiki sestavljeni |
Dojka, novotvorbe |
Receptorji estrogenski |
Brez bolezni, preživetje |
Ciklofosfamid |
Dejavniki tveganja |
Fluorouracil |
Kemoterapija pomožna |
Metotreksat |
Naključno kontrolirane, klinične preiskave |
Ovariektomija |
Policentrične študije |
Prednizon |
Premenopavza |
Prognoza |
Starostni faktorji
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Aebi, S. | ![]() |
Lindtner, Jurij | 05278 |
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