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Vloga cisteinskih proteaz pri diferenciaciji in adheziji promonocitnih celic U937 = The role of cysteine proteases in differentation and adhesion of pro-monocyte U037 cells : diplomska naloga
German, Tamara
Cisteinske proteaze so encimi, ki sodelujejo v stevilnih fizioloskih procesih,njihovo nepravilno delovanje pa je povezano z doloèenimi bolezenskimiprocesi. Katepsina X in B sta edini ...karboksipeptidazi v tej druzini. Vloga katepsina B v organizmu je ze dobro raziskana, kar pa ne velja za katepsin X. Njegova prisotnost v celicah imunskega sistema kaze na vlogo pri imunskem odgovoru, vendar mehanizem delovanja se ni poznan. Z uporabo MTS testa smo doloèili vpliv katepsina B in katepsina X na proliferacijo in adhezijo promonocitnih U937 celic. Pri poskusih smo uporabili nespecifiène sintezne inhibitorje cisteinskih proteaz in pa nevtralizacijska monoklonska protitelesa proti katepsinu B oz. X. Vpliv na proliferacijo celic ni bil opazen pri nobenem od uporabljenih inhibitorjev. Drugaène rezultate pa smo dobili pri doloèanju vpliva cisteinskih proteaz na adhezijo U937 celic diferenciranih s 4Ž-forbol 12- miristat 13-acetatom. Delez adheriranih celic se je moèno zmanjsal z visanjem koncentracij inhibitorjev E-64 (splosni inhibitor cisteinskih proteaz), CA-074 in CA-074-Me (inhibitorja katepsina B in X) ter protiteles proti katepsinu X, nobenega uèinka pa nismo opazili pri nevtralizacijskih protitelesih proti katepsinu B. Kokosji cistatin, ki je moèan inhibitor katepsina B, manj pa katepsina X, je le delno zmanjsal adhezijo diferenciranih U937 celic. Nasi rezultati kazejo, da inhibitorji katepsina X, ne pa katepsina B, zavrejo adhezijo diferenciranih U937 celic, kar kaze na pomembno vlogo tega encima pri regulaciji imunskega odziva.
Type of material - undergraduate thesis
; adult, serious
Publication and manufacture - Ljubljana : [German, T.], 2005
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