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Vpliv spremenjenega izražanja genov za FUBP3 in ANAPC1, na diferenciacijo osteosarkomskih celic HOS in mezenhimskih matičnih celic = The effect of modified FUBP3 and ANAPC1 gene expression on the differentiation of human HOS osteosarcoma and mesenchymal stem cells : [delo za Prešernovo nagrado]Polajžer, SaraKot pri drugih kompleksnih boleznih je genetsko osnovo osteoporoze težko odkriti. V preteklem desetletju je bilo uporabljenih več pristopov za odkrivanje genov, ki vplivajo na krhkost kosti, vključno ... z analizo posameznikov ali družin z ekstremnimi osteoporotičnimi fenotipi in predvsem z vsegenomskimi asociacijskimi študijami (GWAS). V študijah lokusov GWAS, povezanih z nizko mineralno gostoto, sta bila odkrita SNP polimorfizma v genih FUBP3 in ANAPC1, za katera še ni pojasnjeno, ali vplivata na kostno remodulacijo. Namen magistrske naloge je bil funkcijsko vrednotiti vlogo obeh tarčnih genov med osteogeno diferenciacijo. V okviru magistrske naloge smo v osteosarkomske celice HOS vnesli plazmidne vektorje, ki so povzročili zvišano oz. znižano izražanje genov za FUBP3 in ANAPC1 ter opazovali, kako povečano izražanje FUBP3 oziroma znižano izražanje ANAPC1 vpliva na osteogeno diferenciacijo celic HOS. Z merjenjem stopnje mineralizacije smo dokazali, da povečano izražanje FUBP3 oziroma utišanje ANAPC1 upočasni osteogeno diferenciacijo celic HOS. Prav tako smo naredili nukleofekcijo mezenhimskih matičinih celic (MSC) s plazmidom shANAPC1 in opazovali, kako znižanje ANAPC1 vpliva na osteogeno diferenciacijo MSC. Zaradi neuspele nukleofekcije MSC z plazmidom shANAPC1, nismo mogli opredeliti vlogo utišanega izražanja ANAPC1 pri osteogeni diferenciaciji MSC. Z metodo qPCR smo dokazali, da povečano izražanje FUBP3 in znižano izražanje ANAPC1 preprečita zviševanje osteoblastnih markerjev OC, RUNX2 in COL1a1 med osteogeno diferenciacijo ter smo tako dodatno potrdili vpliv spremenjenega izražanja genov FUBP3 in ANAPC1 na osteogeno diferenciacijo celic HOS.Type of material - research project ; adult, seriousPublication and manufacture - Ljubljana : [S. Polajžer], 2023Language - slovenianCOBISS.SI-ID - 174502147
Author
Polajžer, Sara
Other authors
Lovšin, Nika
Topics
Osteoporoza |
GWAS |
FUBP3 |
ANAPC1 |
osteogena diferenciacija |
celična linija HOS |
MSC
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Polajžer, Sara | |
Lovšin, Nika | 19649 |
Source: Personal bibliographies
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