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Rekombinantni človeški proteini - nov nabor učinkovin za zdravljenje luskavice = Recombinant human protein - new palette of drugs for the treatment of psoriasisKristl, JernejLuskavica je kronièna vnetna bolezen, ki prizadene priblizno 2,5 % svetovnega prebivalstva. Klinièno se kaze z odebeljenimi, srebrno-belimi in luskastimi zarisèi na kozi, ki lahko pri bolniku ... povzroèijo hudo nelagodje in boleèino. Za zdravljenje luskavice se veèinoma uporabljajo kortikosteroidi, analogi vitamina D, obsevanje z ultravijolièno A-svetlobo, retinoidi, vendar so obstojeèi naèini zdravljenja nespecifièni in le zavirajo mehanizme njenega nastanka. Napredek rekombinantne DNA-tehnologije in boljse poznavanje patofiziologije luskavice sta botrovala razvoju stevilnih imunomodulacijskih beljakovinskih uèinkovin, ki specifièno zavirajo nastanek luskavice. Bioloske uèinkovine delujejo z neposrednim vplivom na limfocite T, njihovo aktivacijo, migracijo ter izrazanje vnetnih mediatorjev. Kljub vsemu ozdravljenja ne zagotovijo, vendar uèinkoviteje lajsajo njene bolezenske znake, poleg tega so vedno bolj varna. Upostevati moramo namreè, da je zdravljenje luskavice navadno dolgotrajno, med katerim je prisotnost nezelenih uèinkov pri veèini uèinkovin omejitveni dejavnik. V tem èlanku so predstavljena znana dejstva o luskavici, v nadaljevanju pa sledi pregled uèinkovin za njeno zdravljenje s poudarkom na novejsih imunomodulacijskih uèinkovinah.Source: Medicinski razgledi : [medicinski pregledni, strokovni in raziskovalni članki]. - ISSN 0025-8121 (Let. 44, št. 2, 2005, str. 171-182)Type of material - article, component partPublish date - 2005Language - englishCOBISS.SI-ID - 1776241
Author
Kristl, Jernej
Topics
luskavica |
citokini |
rekombiantni proteini |
monoklonalna protitelesa
source: Medicinski razgledi : [medicinski pregledni, strokovni in raziskovalni članki]. - ISSN 0025-8121 (Let. 44, št. 2, 2005, str. 171-182)
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Kristl, Jernej | 24401 |
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