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Effects of proprotein convertase subtilisin-kexin type 9 inhibitors on inflammatory and hemostatic parameters in post myocardial infarction patientsRehberger Likozar, Andreja ; Ugovšek, Sabina ; Šebeštjen, MiranDespite progress in treatment, elevated levels of low-density lipoprotein cholesterol (LDL-C) and lipoprotein (a) (Lp(a)), represent a significant part of the residual risk. Both are associated with ... inflammation and the coagulation fibrinolytic system. The purpose of our research was to evaluate the effect of proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) on lipid parameters and indicators of inflammation, coagulation and fibrinolysis. We included 100 post myocardial infarction (MI) patients with insufficiently controlled LDL-C values despite the maximum dose of statin, and highly elevated Lp(a). Patients received alirocumab or evolocumab (150 mg sc or 140 mg sc every two weeks, respectively), or placebo for 6 months. In patients receiving PCSK9i, a significant decrease in total cholesterol (TC), LDL-C, triglycerides (TG) and Lp(a), and an increase in high density lipoprotein cholesterol (p < 0.001 for all) was found. Before treatment, the concentrations of TC, LDL-C and TG correlated with the concentrations of thrombin activatable fibrinolysis inhibitor (r = 0.41, p < 0.001; r = 0.353, p < 0.001; r = 0.311, p = 0.003, respectively), and plasminogen activator inhibitor-1 (r = 0.302, p = 0.007; r = 0.218, p = 0.049; r = 0.278; p = 0.013, respectively). The concentrations of TC and LDL-C correlated with overall fibrinolytic potential (r = −0.220, p = 0.034; r = −0.207, p = 0.047, respectively). The concentration of TG was related to the concentration of interleukin 6 (r = 0.290, p = 0.004) and interleukin 8 (r = 0.332, p = 0.001). No correlations between Lp(a) and inflammatory or hemostatic variables were found. No associations were found after treatment. Our results show that inflammatory cytokines and fibrinolytic parameters are related to LDL-C and not Lp(a) in post-MI patients before and with neither of them following PCSK9i treatment.Source: European Journal of Pharmacology. - ISSN 0014-2999 (Vol. 963, iss. [article no.] 176232, Jan. 2024, str. 1-8)Type of material - article, component partPublish date - 2024Language - englishCOBISS.SI-ID - 179035139
Author
Rehberger Likozar, Andreja |
Ugovšek, Sabina |
Šebeštjen, Miran
Topics
inflammation |
hemostasis |
PCSK9 inhibitors |
LDL cholesterol |
lipoprotein (a) |
vnetje |
hemostaza |
inhibitorji PCSK9 |
LDL holesterol |
lipoprotein (a)
source: European Journal of Pharmacology. - ISSN 0014-2999 (Vol. 963, iss. [article no.] 176232, Jan. 2024, str. 1-8)
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Rehberger Likozar, Andreja | 55026 |
Ugovšek, Sabina | 57661 |
Šebeštjen, Miran | 19345 |
Source: Personal bibliographies
and: SICRIS
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