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Metilacijski označevalci hepatocelularnega karcinoma v tekočinski biopsiji = Methylation biomarkers of hepatocellular carcinoma in liquid biopsyDraškovič, Tina ; Hauptman, NinaHepatocelularni karcinom (HCC) je najpogostejšeprimarno maligno obolenje jeter, ki ostaja med pe -timi najpogostejšimi vzroki smrti zaradi raka pocelem svetu. Njegov pojav je tesno povezan s ... kroni-čno poškodbo jeter, ki je povezana s procesi vnetja,fibroze in ciroze, zaradi česar pride do okvare pres-novne funkcije organa. Pomembni dejavniki tvega-nja za razvoj HCC so tudi virusne okužbe, pretiranouživanje alkohola in nealkoholna maščobna jetrnabolezen. Poleg genetskih sprememb, ki so pogostoopažene pri HCC, igrajo ključno vlogo tudi epigenet-ske spremembe, med katerimi je DNA metilacija naj-bolj preučevana. Naraščajoče število raziskav kaže navelik potencial DNA metilacije kot ključnega dejav-nika pri različnih vidikih raka, vključno z diagnozo, napovedjo, spremljanjem bolezni in oceno odziva nazdravljenje. V zadnjih letih so tehnološki napredkiomogočili odkrivanje sprememb DNA metilacije vvzorcih tekočinskih biopsij. Raziskave kažejo, da sometilacijski označevalci učinkoviti pri prepoznavanjuHCC v zunajcelični DNA, kar je bilo še dodatno podkrepljeno z odkritjem panelov metilacijskih označe-valcev. Ti paneli so izboljšali občutljivost in specifi-čnost pri diagnosticiranju HCC, kar postavlja temeljeza njihovo pomembno vlogo v diagnostiki HCC.Source: Gastroenterolog : revija Slovenskega združenja za gastroenterologijo in hepatologijo = journal of Slovenian Association for Gastroenterology and Hepatology. - ISSN 1408-2756 (Letn. 27, št. 2/3, dec. 2023, str. 52-58)Type of material - article, component part ; adult, seriousPublish date - 2023Language - slovenianCOBISS.SI-ID - 181708291
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source: Gastroenterolog : revija Slovenskega združenja za gastroenterologijo in hepatologijo = journal of Slovenian Association for Gastroenterology and Hepatology. - ISSN 1408-2756 (Letn. 27, št. 2/3, dec. 2023, str. 52-58)
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Draškovič, Tina | 54662 |
Hauptman, Nina | 27704 |
Source: Personal bibliographies
and: SICRIS
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