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Disease activity in systemic lupus erythematosus : report of the consensus study group of the European workshop for rheumatologyresearch. I, A descriptive analysis of 704 European lupus patients
Vitali, C... ...
Usling a detailed questionnaire, the cumulative historical and current demographic, clinical and serological data on 704 SLE patients from 19 European contries have been assessed. Ninety-three ...percent of the patients were Caucasian and the female/male ratio was 10:1. Analysis of the cumulative incidence showed that arthralgia/arthritis (94 percent), rash (69 percent) Raynaud's phenomenon (49 percent), serositis (44 pervent) and renal disease (38 percent) were the most frequent clinical manifestation. Virtually all the patients (98 percent) were antinuclear antibody positive, while anti-ds DNA antibodies (76 percent), hypocomplementaemia (71 percent) and anti-Ro(SSA) antibodies (35 percent) were frequent serological abnormalities. Whilst much of this data is in line with previous reports, it is notable that renal, lung, and central nervous system involvement and the frequency of rheumatoid factor, anti-Sm and anti-RNP antibodies were much lower than in most comparable series in the United States. We assume that differences and the greater present awareness of lupus could explain this variations. Low dose corticosteroids, non-steroidal anti-inflammatory drugs and anti-malarials were used to treat over half of the patients, 75 percent of whom were between 15 and 55 years of age. This report offers a useful overview of lupus both clinically and serologically in Europe in the 1990's.
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