Akademska digitalna zbirka SLovenije - logo
ALL libraries (COBIB.SI union bibliographic/catalogue database)
  • cAMP directly facilitates Ca-induced exocytosis in bovine lactotrophs
    Sikdar, S... K. ; Zorec, Robert, 1958- ; Mason, W... T.
    We have used the whole cell patch clamp technique on single prolactin-secreting bovine lactotrophs to measure plasma membrane capacitance (Cm), an index of membrane surface area, under voltage-clamp ... during cytosol dialysis with Ca and cAMP. cAMP increased the magnitude and rate of Ca-induced exocytosis (Cm increase) without affecting membrane conductance; however, cAMP had no detectable effect on Cm when intracellular Ca was low. We thus report new evidence that cAMP can facilitate Ca-induced secretion in a synergistic fashion, by acting directly on the secretory apparatus, independently of membrane conductance activation.
    Source: FEBS letters. - ISSN 0014-5793 (Let. 273, št. 1-2, 1990, str. 150-154)
    Type of material - article, component part
    Publish date - 1990
    Language - english
    COBISS.SI-ID - 1873881

source: FEBS letters. - ISSN 0014-5793 (Let. 273, št. 1-2, 1990, str. 150-154)
loading ...
loading ...
loading ...