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Future perspective for the application of predictive biomarker testing in advanced stage non-small cell lung cancer [Elektronski vir]de Jager, Vincent D. ...For patients with advanced stage non-small cell lung cancer (NSCLC), treatment strategies have changed significantly due to the introduction of targeted therapies and immunotherapy. In the last few ... years, we have seen an explosive growth of newly introduced targeted therapies in oncology and this development is expected to continue in the future. Besides primary targetable aberrations, emerging diagnostic biomarkers also include relevant co-occurring mutations and resistance mechanisms involved in disease progression, that have impact on optimal treatment management. To accommodate testing of pending biomarkers, it is necessary to establish routine large-panel next-generation sequencing (NGS) for all patients with advanced stage NSCLC. For cost-effectiveness and accessibility, it is recommended to implement predictive molecular testing using large-panel NGS in a dedicated, centralized expert laboratory within a regional oncology network. The central molecular testing center should host a regional MolecularTumor Board and function as a hub for interpretation of rare and complex testing results and clinical decision-making.Source: The Lancet regional health. Europe [Elektronski vir]. - ISSN 2666-7762 (Vol. 38, Mar. 2024, str. 1-9)Type of material - e-articlePublish date - 2023Language - englishCOBISS.SI-ID - 189048579
Author
de Jager, Vincent D. |
Timens, Wim |
Botling, Johan |
Brčić, Luka |
Büttner, Reinhard |
Fernandes, Maria Gabriela O. |
Havel, Libor |
Hochmair, Maximilian J |
Hofman, Paul M. |
Janssens, Annelies |
Kern, Izidor |
Mohorčič, Katja, 1978-
Topics
predictive biomarker testing |
next-generation sequencing |
non-small cell lung cancer |
pljučne bolezni |
testiranje napovednih (prediktivnih) označevalcev |
sekvenciranje naslednje generacije |
ne-drobnocelični pljučni rak
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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de Jager, Vincent D. | |
Timens, Wim | |
Botling, Johan | |
Brčić, Luka | |
Büttner, Reinhard | |
Fernandes, Maria Gabriela O. | |
Havel, Libor | |
Hochmair, Maximilian J | |
Hofman, Paul M. | |
Janssens, Annelies | |
Kern, Izidor | 15781 |
Mohorčič, Katja, 1978- | 30985 |
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