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Enhanced perfusion following exposure to radiotherapy : a theoretical investigationKöry, Jakub ...Tumour angiogenesis leads to the formation of blood vessels that are structurally and spatially heterogeneous. Poor blood perfusion, in conjunction with increased hypoxia and oxygen heterogeneity, ... impairs a tumour's response to radiotherapy. The optimal strategy for enhancing tumour perfusion remains unclear, preventing its regular deployment in combination therapies. In this work, we first identify vascular architectural features that correlate with enhanced perfusion following radiotherapy, using in vivo imaging data from vascular tumours. Then, we present a novel computational model to determine the relationship between these architectural features and blood perfusion in silico. If perfusion is defined to be the proportion of vessels that support blood flow, we find that vascular networks with small mean diameters and large numbers of angiogenic sprouts show the largest increases in perfusion post-irradiation for both biological and synthetic tumours. We also identify cases where perfusion increases due to the pruning of hypoperfused vessels, rather than blood being rerouted. These results indicate the importance of considering network composition when determining the optimal irradiation strategy. In the future, we aim to use our findings to identify tumours that are good candidates for perfusion enhancement and to improve the efficacy of combination therapies.Source: PLoS computational biology. - ISSN 1553-734X (Vol. 20, no. 2, 2024, str. 1011252-1-1011252-32)Type of material - article, component part ; adult, seriousPublish date - 2024Language - englishCOBISS.SI-ID - 190484227
Author
Köry, Jakub |
Narain, Vedang |
Stolz, Bernadette J. |
Käppler, Jakob Raphael |
Markelc, Boštjan |
Muschel, Ruth J. |
Maini, Philip K. |
Pitt-Francis, Joe |
Byrne, Helen
Topics
tumorska angiogeneza |
perfuzija |
radioterapija |
onkologija |
tumour angiogenesis |
perfusion |
radiotherapy |
oncology
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source: PLoS computational biology. - ISSN 1553-734X (Vol. 20, no. 2, 2024, str. 1011252-1-1011252-32)
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Köry, Jakub | ![]() |
Narain, Vedang | ![]() |
Stolz, Bernadette J. | ![]() |
Käppler, Jakob Raphael | ![]() |
Markelc, Boštjan | 32175 |
Muschel, Ruth J. | ![]() |
Maini, Philip K. | ![]() |
Pitt-Francis, Joe | ![]() |
Byrne, Helen | ![]() |
Source: Personal bibliographies
and: SICRIS
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