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  • Comparative fitting of mathematical models to carvedilol release profiles obtained from hypromellose matrix tablets [Elektronski vir]
    Ojsteršek, Tadej, farmacevt ; Vrečer, Franc ; Hudovornik, Grega, farmacevt
    The mathematical models available in DDSolver were applied to experimental dissolution data obtained by analysing carvedilol release from hypromellose (HPMC)-based matrix tablets. Different ... carvedilol release profiles were generated by varying a comprehensive selection of fillers and carvedilol release modifiers in the formulation. Model fitting was conducted for the entire relevant dissolution data, as determined by using a paired t-test, and independently for dissolution data up to approximately 60% of carvedilol released. The best models were selected based on the residual sum of squares (RSS) results used as a general measure of goodness of fit, along with the utilization of various criteria for visual assessment of model fit and determination of the acceptability of estimated model parameters indicating burst release or lag time concerning experimental dissolution results and previous research. In addition, a model-dependent analysis of carvedilol release mechanisms was carried out.
    Source: Pharmaceutics [Elektronski vir]. - ISSN 1999-4923 (Vol. 16, issue 4, [article no.] 498, 2024, 29 str.)
    Type of material - e-article ; adult, serious
    Publish date - 2024
    Language - english
    COBISS.SI-ID - 191480323

    Link(s):

    https://www.mdpi.com/1999-4923/16/4/498
    DOI

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