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Zdravljenje parodontitisa z Arestinom pri bolnikih s sladkorno boleznijo = Periodontal treatment with Arestin in diabetic patients
Schara, Rok ; Medvešček, Marko ; Skalerič, Uroš, 1945-2023
Background: The aim of Ihis randomised pilot clinical trial was to determine if type 1 diabetic patients with periodontitis will experience a reduction in HbA1c levels when treated with locally ...delivered minocycline microspheres (Arestin) as an adjunct to scaling and root planing. Subjects and methods: Twenty adult patients with poorly controlled diabetes (HbA1c > 7.5%) and periodontitis. as determined by the presence of four teeth with > 5 mm periodontal pockets, were included in the study. Two of the patients had 6-9 mm pockets and bleeding on probing. All patients received full-mouth scaling and root planing at baseline. In the test group (10 patients), Arestin was applied into all pockets > 5 mm at baseline and again at 12 weeks. Probing depth (PD), clinical attachment level (CAL), plaque lndex (PI), gingival index(GI). and HbA1c were evaluated at baseline and at 6, 12, 18 and 24 weeks.Results: The results showed that local administration of Arestin as an adjunct to scaling and root planing was significantly more effective in reducing probing depths and providing a gain in clinical attachment levels than scaling and root planing alone. Hb1Ac levels were reduced in all patients, but the difference between the test and control groups was not significant. Conclusions: We conclude that local administration of Arestin in conjunction with scaling and root planing significantly reduces the probing depth in type I diabetic patients.
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