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Systemic up-regulation of sTNFR2 and IL-6 in Porphyromonas gingivalis pneumonia in mice
Petelin, Milan ...
Aspiration pneumonia is a common cause of death in older people, and the pathophysialogy is a chronic respiratory failure with a mild airway inflammation. In this study, we established a mild ...inflammatory pneumonia model using Porphyromonas gingivalis (Pg) pathogen-infected mice.It elucidatedthe effects of Pg-infected pneumonia on proinflammatory cytokines tumor necrosis factor (TNF)-alpha, interleukin-6 (IL-6), and IL-1beta production in both lung tissue and serum. We also elucidated production of soluble (s) TNF receptor (R)s, because TNF-alpha is considered to be a dominant inflammatory mediator. Lung TNF-alpha Ievels significantly increased at 2 h after infection, and rapidly returned to basal level at 24 h. Consistent with increase of TNF-alpha, remarkable increase of sTNFR2 but not sTNFR1 was detected in lung tissue from 2 to 72 h. Interestingly, sTNFR2/sTNFR1 ratio was significantly enhanced at 2 h in serum. In addition, lung IL-1beta and IL-6 levels also significantly increased from 2 to 24 h. Importantly, we found that IL-6 Ievels in serum reflected its local Ievel. These results may suggest that systemically produced sTNFR2 and IL-6 could be a key role to modulate proinflammatory activities of TNF-alpha in Pg-induced lung inflammation simulated aspiration pneumonia.
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