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Ultra-hypofractionated one-week locoregional radiotherapy for patients with early breast cancer [Elektronski vir] : acute toxicity resultsRatoša, Ivica ...Purpose: Moderate hypofractionated radiotherapy is the standard of care for all patients with breast cancer, irrespective of stage or prior treatments. While extreme hypofractionation is accepted for ... early-stage tumours, its application in irradiating locoregional lymph nodes remains controversial. Materials and methods: A prospective registry analysis from July 2020 to September 2023 included 276 patients with early-stage breast cancer treated with one-week ultra-hypofractionation (UHF) at 26 Gy in 5 fractions on the whole breast (58.3 %) or thoracic wall (41.7 %) and ipsilateral regional lymph nodes and simultaneous integrated boost (58.3 %). Primary endpoint was assessment of acute adverse events (AEs). Secondarily, onset of early-delayed toxicity was assessed. A minimum 6-month follow-up was required for assessing potential treatment-related early-delayed complications. Acute or late complications attributable to treatment were assessed at inclusion using the Common Terminology Criteria for Adverse Events (CTCAE) v5.0 criteria. Results: With a median follow-up of 19 months (range 1–49 months), 159 (57.6 %) patients reported AEs, predominantly grade (G) 1 (n = 139, 50.4 %) and G2 (n = 20, 7.8 %). Skin acute toxicity was common (G1/2: 134, G3: 14), while breast oedema occurred in 10 patients (G1: 9, G2: 1), and 15.9 % reported breast pain (G1: 42, G2: 2). Ipsilateral arm oedema was observed in 1.8 % patients. For patients with a follow-up beyond 6 months (n = 213), 23.4 % patients reported G1/G2 skin AEs, 8.8 % had G1/G2 breast/chest wall oedema, and 8.9 % experienced arm lymphedema. There were no cases of brachial plexopathy or G3 toxicity in this group of patients. Conclusions: One-week UHF adjuvant locoregional radiation is well-tolerated, displaying low-toxicity profiles comparable to other studies using similar irradiation schedules.Source: Clinical and translational radiation oncology. - ISSN 2405-6308 (Vol. 46, 2024, str. 100764-1-100764-11)Type of material - e-article ; adult, seriousPublish date - 2024Language - englishCOBISS.SI-ID - 192573443
Author
Ratoša, Ivica |
Montero, Angel |
Ciervide, Raquel |
Alvarez, Beatriz |
García-Aranda, Mariola |
Valero, Jeannette |
Lopez, Mercedes |
Zucca, Daniel |
Hernando, Ovidio |
Rubio, Carmen
Topics
obsevanje dojke |
regionalno obsevanje tumorjev |
ultra-hipofrakcinacija |
breast radiotherapy |
regional node irradiation |
ultra-hypofractionation
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Ratoša, Ivica | 34883 |
Montero, Angel | ![]() |
Ciervide, Raquel | ![]() |
Alvarez, Beatriz | ![]() |
García-Aranda, Mariola | ![]() |
Valero, Jeannette | ![]() |
Lopez, Mercedes | ![]() |
Zucca, Daniel | ![]() |
Hernando, Ovidio | ![]() |
Rubio, Carmen | ![]() |
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