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Urothelial injuries and the early wound healing response : tight junctions and urothelial cytodifferentiationErdani-Kreft, Mateja ...Using primary explant cultures of mouse bladder, the early response of the urothelium after superficial and full-thickness injuries was investigated. In such an in vitro wound healing model, explant ... surfaces with a mostly desquamated urothelial superficial layer represented superficial wounds, and the exposed lamina propria at the cut edges of the explants represented full-thickness wounds. The urothelial cell ultrastructure, the expression and subcellular distribution of the tight junctional protein occludin, and differentiation-related proteins CK 20, uroplakins, and actin were followed. Since singular terminally differentiated superficial cells remained on the urothelium after superficial injury (i.e., original superficial cells), we sought to deterrnine their role during the urothelial wound-heafing process. Ultrastructural and immunocytochemical studies have revealed that restored tight junctions are the earliest cellular event during the urothelial superficial and full-thickness wound-healing process. Occludin-containing tight junctions are developed before the new superficial cells are terminally differentiated. New insights into the urothelium wound-healing process were provided by demonstrating that the original superficial cells contribute to the urothelium wound healing by developing tight junctions with de novo differentiated superficial cells and by stretching, thus providing a large urothelial surface with asymmetric unit membrane plaques.Source: Histochemistry and cell biology. - ISSN 0948-6143 (Letn. 123, 2005, str. 529-539)Type of material - article, component partPublish date - 2005Language - englishCOBISS.SI-ID - 19284697
Author
Erdani-Kreft, Mateja |
Sterle, Maksimiljan |
Veranič, Peter |
Jezernik, Kristijan
Topics
Urothelium |
Bladder |
Injuries |
Ultrastructure |
Tight Junctions |
Wound Healing |
Cell Differentiation |
Cells, Cultured |
Microscopy, Electron |
Fluorescent Antibody Technique, Indirect |
Microscopy, Immunoelectron |
Mice, Inbred Strains |
Celična diferenciacija |
Rana, celjenje |
Sečni mehur |
Tesni stiki |
Urotelij |
Celične kulture |
Fluorescenčno protitelo, tehnika indirektna |
Mikroskopija elektronska |
Mikroskopija imunoelektronska |
Miši, čiste linije
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Erdani-Kreft, Mateja | 15873 |
Sterle, Maksimiljan | 03400 |
Veranič, Peter | 08279 |
Jezernik, Kristijan | 05277 |
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