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Radiotherapy for metastatic epidural spinal cord compression with increased doses [Elektronski vir] : final results of the RAMSES-01 trialRades, Dirk ...Patients with metastatic epidural spinal cord compression (MESCC) and favorable survival prognoses may benefit from radiation doses exceeding 10 × 3.0 Gy. In a multi-center phase 2 trial, patients ... receiving 15 × 2.633 Gy (41.6 Gy10) or 18 × 2.333 Gy (43.2 Gy10) were evaluated for local progression-free survival (LPFS), motor/sensory functions, ambulatory status, pain, distress, toxicity, and overall survival (OS). They were compared (propensity score-adjusted Cox regression) to a historical control group (n = 266) receiving 10 × 3.0 Gy (32.5 Gy10). In the phase 2 cohort, 50 (of 62 planned) patients were evaluated for LPFS. Twelve-month rates of LPFS and OS were 96.8% and 69.9%, respectively. Motor and sensory functions improved in 56% and 57.1% of patients, and 94.0% were ambulatory following radiotherapy. Pain and distress decreased in 84.4% and 78.0% of patients. Ten and two patients experienced grade 2 and 3 toxicities, respectively. Phase 2 patients showed significantly better LPFS than the control group (p = 0.039) and a trend for improved motor function (p = 0.057). Ambulatory and OS rates were not significantly different. Radiotherapy with 15 × 2.633 Gy or 18 × 2.333 Gy was well tolerated and appeared superior to 10 × 3.0 Gy.Source: Cancers [Elektronski vir]. - ISSN 2072-6694 (Vol. 16, no. 6, 2024, str. 1149-11149-12)Type of material - e-article ; adult, seriousPublish date - 2024Language - englishCOBISS.SI-ID - 193339907
Author
Rades, Dirk |
Lomidze, Darejan |
Jankarashvili, Natalia |
Lopez Campos, Fernando |
Šegedin, Barbara |
Grošelj, Blaž |
Staackmann, Christian |
Kristiansen, Charlotte |
Dennis, Kristopher |
Schild, Steven E.
Topics
visoko konformalna radioterapija |
metastastka epiduralna utesnitev hrbtenjače |
radioterapija |
highly conformal radiotherapy |
metastatic epidural spinal cord compression |
radiotherapy
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Rades, Dirk | ![]() |
Lomidze, Darejan | ![]() |
Jankarashvili, Natalia | ![]() |
Lopez Campos, Fernando | ![]() |
Šegedin, Barbara | 27754 |
Grošelj, Blaž | 38482 |
Staackmann, Christian | ![]() |
Kristiansen, Charlotte | ![]() |
Dennis, Kristopher | ![]() |
Schild, Steven E. | ![]() |
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