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Modelna simulacija vpliva aspirina na produkcijo eikozanoidov v levkocitih : diplomsko deloMaglica, SamoV diplomskem delu apliciramo fizikalno-matematični model presnove arahidonske kisline (AA) na razlago pojava aspirinsko inducirane astme oz. aspirinske intolerance. Aspirinska intoleranca je vnetna ... bolezen zgornjih in spodnjih dihalnih poti, ki prizadene aspirinsko intolerantne astmatike. Klinični znaki aspirinske intolerance se pojavijo po zaužitju aspirina ali kakšnega drugega nesteroidnega antirevmatika (NSAR). V delu opišemo in nato v nekaterih podrobnostih dopolnimo že obstoječ matematični model presnove AA, ki je plod izvirnega raziskovalnega dela članov Oddelka za fiziko na FNM UM. Omenjeni model nadgradimo z upoštevanjem ireverzibilne vezave aspirina na dva encima, ki ju aspirin inhibira. To sta encima prostaglandin H sintaza 1 in 2 (PGHS1 in PGHS2). Originalni model namreč upošteva, da se NSAR reverzibilno veže na encima in ju inhibira, kar velja za večino NSAR, ne velja pa za aspirin. Le-ta se na omenjena encima kovalentno veže in ju s tem trajno onemogoči. Z modelom realistično napovemo časovne poteke koncentracij prostaglandinov in levkotrienov v odvisnosti od različnih oralno zaužitih doz aspirina ter določimo mejne doze in napovemo čas trajanja bronhokonstrikcije po zaužitju tipičnih doz aspirina pri aspirinsko intolerantnih astmatikih. Napoved časa trajanja bronhokonstrikcije in mejnih doz temelji na izračunu razmerja med koncentracijama prostaglandina E2 (PGE2) in levkotriena C4 (LTC4). Za aspirinsko intolerantne astmatike je značilno, da je to razmerje pred in po zaužitju aspirina manjše od ena, medtem ko je za zdrave osebke in za aspirinsko tolerantne astmatike vselej večje od ena. Vzrok za to naj bi bile spremenjene ekspresije encimov PGHS1 in PGHS2 ter encima levkotrien C4 sintaze (LTC4S). Po originalnem modelu povzamemo opis različnih populacij, ki se razlikujejo po ekspresijah teh encimov, izvedemo modelne simulacije in primerjamo dobljene rezultate.Type of material - undergraduate thesis ; adult, seriousPublication and manufacture - Maribor : [S. Maglica], 2013Language - slovenianCOBISS.SI-ID - 19917064
Author
Maglica, Samo
Other authors
Fajmut, Aleš |
Dobovišek, Andrej
Topics
Univerzitetna in visokošolska dela |
fizika |
aspirin |
intoleranca |
arahidonska kislina |
levkotrieni |
prostaglandini |
matematični model |
astma |
encimi |
inhibicija |
biofizika |
diplomska dela
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Library/institution |
City | Acronym | For loan | Other holdings |
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Miklošič Library FPNM, Maribor | Maribor | PEFMB |
reading room 1 cop.
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DRS, in which the journal is indexed
Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Maglica, Samo | ![]() |
Fajmut, Aleš | 19553 |
Dobovišek, Andrej | 26447 |
Source: Personal bibliographies
and: SICRIS
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