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The impact of phospholipid-based liquid crystals’ microstructure on stability and release profile of ascorbyl palmitate and skin performance [Elektronski vir]Zvonar Pobirk, Alenka, 1980- ...The drug delivery potential of liquid crystals (LCs) for ascorbyl palmitate (AP) was assessed, with the emphasis on the AP stability and release profile linked to microstructural rearrangement taking ... place along the dilution line being investigated by a set of complementary techniques. With high AP degradation observed after 56 days, two stabilization approaches, i.e., the addition of vitamin C or increasing AP concentration, were proposed. As a rule, LC samples with the lowest water content resulted in better AP stability (up to 52% of nondegraded AP in LC1 after 28 days) and faster API release (~18% in 8 h) as compared to the most diluted sample (29% of nondegraded AP in LC8 after 28 days, and up to 12% of AP released in 8 h). In addition, LCs exhibited a skin barrier-strengthening effect with up to 1.2-fold lower transepidermal water loss (TEWL) and 1.9-fold higher skin hydration observed in vitro on the porcine skin model. Although the latter cannot be linked to LCs’ composition or specific microstructure, the obtained insight into LCs’ microstructure contributed greatly to our understanding of AP positioning inside the system and its release profile, also influencing the overall LCs’ performance after dermal application.Source: Molecules [Elektronski vir]. - ISSN 1420-3049 (Vol. 29, iss. 13, [article no.] 3173, 2024, str. 1-20)Type of material - e-article ; adult, seriousPublish date - 2024Language - englishCOBISS.SI-ID - 200578819
Author
Zvonar Pobirk, Alenka, 1980- |
Roškar, Robert, 1975- |
Bešter-Rogač, Marija |
Gašperlin, Mirjana |
Gosenca Matjaž, Mirjam
Topics
Dostavni sistemi |
Tekoči kristali |
lamelarni tekoči kristali |
mikrostruktura |
askorbil palmitat |
stabilnost |
sistemi za dostavo kože |
lamellar liquid crystals |
microstructure |
ascorbyl palmitate |
stability |
skin delivery systems
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Author | Zvonar Pobirk, Alenka, 1980- ... |
Title | The impact of phospholipid-based liquid crystals’ microstructure on stability and release profile of ascorbyl palmitate and skin performance [Elektronski vir] |
Publication date | 2024-07-03 |
COBISS.SI-ID | 200578819 |
Publication version in repository | Publisher's version |
Publication licence | Creative Commons Attribution 4.0 International |
Embargo | Immediate publication for public |
Project(s) from which the publication was funded
Title | Acronym | Project ID | Funder |
---|---|---|---|
Farmacevtska tehnologija: od dostavnih sistemov učinkovin do terapijskih izidov zdravil pri otrocih in starostnikih | P1-0189-2018 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
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Zvonar Pobirk, Alenka, 1980- | 26226 |
Roškar, Robert, 1975- | 23549 |
Bešter-Rogač, Marija | 04657 |
Gašperlin, Mirjana | 11789 |
Gosenca Matjaž, Mirjam | 29887 |
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