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Chromophobe renal cell carcinoma with microcystic and adenomatous arrangement and pigmentation - a diagnostic pitfall. Morphological, immunohistochemical, ultrastructural and molecular genetic report of 20 casesHes, O. ...We present clinical, morphological, immunohitochemical, ultrastructural and molecular genetic features of 20 cases of a peculiar form of chromophobe renalcarcinoma (CRCC) with morphology differing ... from that of conventional CRCC. Microscopically, the typical features of the tumors were microcystic arrangement and formation of adenomatous structures. Microcystic areas were composed of smaller cosinophilic and bigger pale cells having cytological appearance typical of conventional CRCC. Cytological features of the adenomatous structures were mostly different from those of conventional CRCC. They had a typical columnar arrangement with nuclei positioned at the base of the glandular structures and a small amount of a deeply eosinophilic cytoplasmoften endowed with brush border facing the lumen of the glands. In addition, all the tumors showed a brown pigmentation. The pigmentation was located mostly extracellularly, where it formed pools of heavy deposits. Microscopic calcifications present in all cases formed psammoma bodies or elsethe calcifications were more extensive and amorphous in shape. Ultrastructurally. the cells showed features characteristic of CRCC: typical cytoplasmic vesicles were 100-700 nm in size and mitochondria had tubulovesicular, lamellar or circular cristae. Some tumor cells contained dark, variously sized electron-dense pigment granules. Neither melanosomes normembrane-bound neurosecretory granules were seen. Using fluorescence in-situ hybridization probes for chromosomes 1, 2, 6, 10, 13, 17 and 21, the tumors revealed massive loss of tested chromosomes typical for conventional CRCC. Monosomy of chromosomes 1, 2, 6, 10, 13 and 21 was found in 100, 36, 91,82, 82, 82 and 64% of cases, respectively. None of the cases showed mutation of axons 9. 11, l3 and 17 of the c-kit gene. (Abstract truncated at 2000 characters)Source: Virchows Archiv. - ISSN 0945-6317 (Letn. 446, 2005, str. 383-393)Type of material - article, component partPublish date - 2005Language - englishCOBISS.SI-ID - 20230873
Author
Hes, O. |
Lamovec, Janez
Topics
Kidney Neoplasms |
Pathology |
Genetics |
Metabolism |
Adenoma, Oxyphilic |
Pathology |
Genetics |
Metabolism |
Carcinoma, Renal Cell |
Pathology |
Genetics |
Metabolism |
Sex Factors |
Age Factors |
Pigments |
In Situ Hybridization, Fluorescence |
Follow-Up Studies |
Diagnosis, Differential |
Dna Mutational Analysis |
Cytoplasm |
Ultrastructure |
Adenom oksifilni |
Karcinom ledvičnih celic |
Ledvica, novotvorbe |
Citoplazma |
DNA mutacijska analiza |
Diagnostika diferencialna |
In situ hibridizacija fluorescenčna |
Pigmenti |
Sledilne študije |
Spolni faktorji |
Starostni faktorji
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Hes, O. | ![]() |
Lamovec, Janez | 04376 |
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